中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (12): 793-795.

• 论著 • 上一篇    下一篇

华东地区汉族斑秃与HLA-DRB1*03、*04、*11基因多态性的关联研究

齐思思 徐峰 慕彰磊 盛友渔 楼玮 任永涛 萧名杰 张心菊 杨勤萍   

  1. 复旦大学附属华山医院皮肤科 上海复旦大学附属华山医院皮肤科 上海复旦大学附属华山医院皮肤科 上海复旦大学附属华山医院皮肤科
  • 收稿日期:2008-06-16 修回日期:2008-07-16 发布日期:2008-12-15
  • 通讯作者: 齐思思 E-mail:qi_si_si@yahoo.com.cn

Association of HLA-DRB1*03, *04 and *11 alleles with alopecia areata in Han Nationality in East China

  

  • Received:2008-06-16 Revised:2008-07-16 Published:2008-12-15

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摘要： 目的 探讨中国华东地区汉族人群HLA-DRB1基因与斑秃发病、临床特点的关系。方法 采用序列特异性引物PCR（PCR-SSP）技术对已确诊为斑秃的158例和正常人对照组172例进行HLA-DRB1基因多态性分析。并比较斑秃患者不同发病年龄、发病次数、病程、家族史及严重程度与HLA-DRB1基因的关联性。结果 斑秃组HLA-DRB1*03、HLA-DRB1*11等位基因频率与对照组差异无统计学意义。斑秃组HLA-DRB1*04（OR = 1.99，Pc = 0.01）等位基因频率明显高于对照组。与正常人对照组比较，斑秃晚发组（发病年龄 > 16岁）（OR = 1.94，Pc = 0.02）、斑秃复发组（发病次数 > 1）和初发组（OR = 2.49、Pc = 0.02，OR = 1.83、Pc = 0.04）、病程 > 1年的患者（OR = 2.94，Pc = 0.01）、无家族史的患者（OR = 1.97，Pc = 0.02）、严重斑秃患者（OR = 3.53，Pc = 0.00）HLA-DRB1*04等位基因频率均显著升高。结论 中国华东地区汉族人群HLA-DRB1*04等位基因与斑秃发病、临床分型显著相关。

关键词: 斑秃;基因, MHCⅡ类;等位基因

Abstract: Objective To investigate the association of HLA-DRB1*03, *04 and *11 alleles with alopecia areata （AA） in Han Nationality in East China. Methods Polymerase chain reaction-sequence specific primer （PCR-SSP） method was conducted in 158 Chinese Han patients with AA as well as in 172 healthy human controls in East China. The relationships of HLA-DRB1 polymorphism to age of onset, episode frequency, clinical course, family history, and severity of AA were evaluated. Results No significant differences were observed for the frequency of HLA DRB1*03, *11 alleles between the patients and human controls, while increased frequency of HLA-DRB1*04 was observed in patients （OR = 1.99, Pc = 0.01）. Multiple logistic regression analysis revealed that HLA-DRB1*04 was more prevalent in patients with an onset after 16 years of age （OR = 1.94, Pc = 0.02）, those without family history （OR = 1.97, Pc = 0.02）, those with recurrent AA （OR = 2.49, Pc = 0.02）, those with a clinical course of more than 1 year （OR = 2.94, Pc = 0.01）, those with severe AA （OR = 3.53, Pc = 0.00） and those with single episode of AA （OR = 1.83, Pc = 0.04） in comparison with the normal human controls. Conclusion This study demonstrates that HLA-DRB1 *04 allele is associated with the occurrence and clinical types of AA in Han Nationality in East China.