以轻链型淀粉样变性和持久性隆起性红斑为首要临床表现的IgA单克隆免疫球蛋白病1例并文献复习

doi:10.35541/cjd.20220382

中华皮肤科杂志 ›› 2023, e0220382.doi: 10.35541/cjd.20220382

以轻链型淀粉样变性和持久性隆起性红斑为首要临床表现的IgA单克隆免疫球蛋白病1例并文献复习

韩冰周俊峰刘鹤松牟岳明王虹

吉林大学第一医院皮肤科，长春 130021

收稿日期:2022-05-30 修回日期:2023-08-06 发布日期:2023-12-12
通讯作者: 王虹 E-mail:w_hong@jlu.edu.cn
基金资助:
吉林省医疗卫生人才专项（JLSCZD2019-024）

IgA monoclonal gammopathy with light chain amyloidosis and erythema elevatum diutinum as the primary clinical manifestations: a case report and literature review

Han Bing, Zhou Junfeng, Liu Hesong, Mu Yueming, Wang Hong

Department of Dermatology, the First Hospital of Jilin University, Changchun 130021, China

Received:2022-05-30 Revised:2023-08-06 Published:2023-12-12
Contact: Wang Hong E-mail:w_hong@jlu.edu.cn
Supported by:
Medical and Health Talents Project of Jilin Province（JLSCZD2019-024）

摘要/Abstract

摘要： 患者男，74岁。躯干、四肢皮肤反复瘀斑、丘疹、结节伴瘙痒、疼痛6年，加重2周入院。患者6年前无明显诱因左上肢皮肤出现数枚指甲大小紫红色瘀斑和斑丘疹，自觉瘙痒、疼痛，部分可自行消退，但反复发生，并逐渐增多、增大，形成结节及斑块，破溃愈合后形成瘢痕……

韩冰周俊峰刘鹤松牟岳明王虹. 以轻链型淀粉样变性和持久性隆起性红斑为首要临床表现的IgA单克隆免疫球蛋白病1例并文献复习[J]. 中华皮肤科杂志, 2023,e0220382. doi:10.35541/cjd.20220382

Han Bing, Zhou Junfeng, Liu Hesong, Mu Yueming, Wang Hong. IgA monoclonal gammopathy with light chain amyloidosis and erythema elevatum diutinum as the primary clinical manifestations: a case report and literature review[J]. Chinese Journal of Dermatology,2023,e0220382. doi:10.35541/cjd.20220382

参考文献 10

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［3］	中国系统性轻链型淀粉样变性协作组, 国家肾脏疾病临床医学研究中心, 国家血液系统疾病临床医学研究中心. 系统性轻链型淀粉样变性诊断和治疗指南（2021年修订）［J］. 中华医学杂志, 2021,101（22）:1646⁃1656. doi: 10.3760/cma.j.cn11 2137⁃20210302⁃00534.
［4］	Patnala GP, Sunandini AP, Rayavarapu R, et al. Erythema elevatum diutinum in association with IgA monoclonal gammopathy: a rare case report［J］. Indian Dermatol Online J, 2016,7（4）:300⁃303. doi: 10.4103/2229⁃5178.185472.
［5］	Thomas CL, Ffolkes L, Akhras V. A case of mistaken identity: unilateral erythema elevatum diutinum associated with IgA paraproteinaemia［J］. Clin Exp Dermatol, 2015,40（7）:761⁃764. doi: 10.1111/ced.12622.
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［8］	Chowdhury MM, Inaloz HS, Motley RJ, et al. Erythema elevatum diutinum and IgA paraproteinaemia: ′a preclinical iceberg′ ［J］. Int J Dermatol, 2002,41（6）:368⁃370. doi: 10.1111/j.1365⁃4632. 2002.1432_4.x.
［9］	Manni E, Cervadoro E, Papineschi F. Case of erythema elevatum diutinum associated with IgA paraproteinemia successfully controlled with thalidomide and plasma exchange［J］. Ther Apher Dial, 2015,19（2）:195⁃196. doi: 10.1111/1744⁃9987.12234.
［10］	刘璇, 陈柳青. 持久性隆起性红斑与坏疽性脓皮病合并IgA单克隆丙种球蛋白血症一例［J］. 中华皮肤科杂志, 2018,51（2）:155⁃156. doi: 10.3760/cma.j.issn.0412⁃4030.2018.02.023.

以轻链型淀粉样变性和持久性隆起性红斑为首要临床表现的IgA单克隆免疫球蛋白病1例并文献复习

IgA monoclonal gammopathy with light chain amyloidosis and erythema elevatum diutinum as the primary clinical manifestations: a case report and literature review

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