中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (6): 361-363.

• 论著 • 上一篇    下一篇

54例结节性硬化症皮损的特点及其发生年龄分析

赵丽 叶静 李存江 等   

  1. 北京 首都医科大学宣武医院神经内科（联系方法：见地址） 北京 首都医科大学宣武医院神经内科 北京 首都医科大学宣武医院神经内科
  • 收稿日期:2007-07-03 修回日期:2007-09-10 发布日期:2008-06-15
  • 通讯作者: 赵丽 E-mail:halljolly@163.com

Analysis of onset age and cutaneous lesions in 54 patients with tuberous sclerosis

  

  • Received:2007-07-03 Revised:2007-09-10 Published:2008-06-15

PDF

98

摘要： 目的 探讨结节性硬化症皮肤皮损特点及首发年龄特点。方法 收集并分析54例结节性硬化症皮损资料。结果 血管纤维瘤的出现率为72.5%，发病年龄的中位数为7岁，1 ～ 9岁为高峰期；甲周纤维瘤的出现率为26%，发病年龄的中位数为14岁，10 ～ 19岁为高峰期；色素脱失斑的出现率为70%，发病年龄的中位数为0.2岁，1岁以内为高峰期；鲨鱼皮斑的出现率为48%，发病年龄的中位数为6岁，1 ～ 9岁为高峰期。 结论 结节性硬化症的皮损发生率高，多在幼年发病。

Abstract: Objective To analyze the features of cutaneous lesions and age of onset of tuberous sclerosis （TS）. Methods A total of 54 TS patients were recruited; their clinical data were analysed. Results The occurance of facial angiofibromas, periungual fibromas, hypomelanotic macules and shark macules was 72.5%, 26%, 70% and 48%, respectively, and the median age of onset of these lesions was 7, 14, 0.2 and 6 years, respectively, with a peak at 1-9, 10-19, < 1 and 1-9 years, respectively. Conclusions Cutaneous lesions are commonly seen in TS, and most of them develop early in life.