中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (10): 927-930.doi: 10.35541/cjd.20191126

• 综述 • 上一篇    下一篇

拉莫三嗪所致药疹的研究进展

肖扬    张晓光   

  1. 河北医科大学第二医院皮肤科，石家庄  050000
  • 收稿日期:2019-12-02 修回日期:2020-08-17 发布日期:2021-09-28
  • 通讯作者: 张晓光 E-mail:zhangxiaoguang078@163.com
  • 基金资助:
    河北省医学科学研究重点课题计划项目（20160131）

Lamotrigine-induced drug eruption

Xiao Yang, Zhang Xiaoguang   

  1. Department of Dermatology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:2019-12-02 Revised:2020-08-17 Published:2021-09-28
  • Contact: Zhang Xiaoguang E-mail:zhangxiaoguang078@163.com
  • Supported by:
    Hebei Medical Science Research Key Project Plan（20160131）

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摘要： 【摘要】 拉莫三嗪（LTG）是一种新型治疗癫痫、双向情感障碍及神经痛的药物，常见的不良反应是药疹，如固定型药疹、急性泛发型发疹型脓疱病、中毒性表皮松解坏死型药疹、药物超敏反应综合征等。LTG引起药疹包括免疫和非免疫机制。HLA等位基因与LTG引起的药疹相关，有种族差异，且与药疹类型有关。本文总结LTG引起的药疹病因、发病机制、临床特点等，以期指导临床用药。

关键词: 药疹, HLA抗原, 拉莫三嗪

Abstract: 【Abstract】 Lamotrigine is a new type of drug for the treatment of epilepsy, bipolar disorder and neuralgia. Drug eruption is the common adverse reaction to lamotrigine, such as fixed drug eruption, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome, etc. The pathogenesis of lamotrigine-induced drug eruptions includes immune and non-immune mechanisms. HLA alleles are related to drug eruptions caused by lamotrigine, and their relationship differs among different races and type of drug eruptions. This review summarizes the etiology, pathogenesis and clinical characteristics of drug eruptions caused by lamotrigine, aiming to guide clinical treatment.

Key words: Drug eruptions, HLA antigens, Lamotrigine