中华皮肤科杂志 ›› 2018, Vol. 51 ›› Issue (5): 363-365.doi: 10.3760/cma.j.issn.0412-4030.2018.05.009

• 研究报道 • 上一篇    下一篇

51例女童尖锐湿疣临床分析

黄丹1,鞠梅2,常宝珠3,陈旭4,张小华1,朱艳1,周亚男1,许南1,陈崑3,顾恒1   

  1. 1. 中国医学科学院皮肤病研究所理疗科
    2. 南京 中国医学科学院北京协和医学院皮肤病医院
    3. 南京 中国医学科学院北京协和医学院皮肤病研究所
    4. 中国医学科学院北京协和医学院皮肤病研究所
  • 收稿日期:2017-09-22 修回日期:2018-03-12 出版日期:2018-05-15 发布日期:2018-05-02
  • 通讯作者: 顾恒 E-mail:doctor_guheng@hotmail.com
  • 基金资助:
    江苏省自然科学基金;中国医学科学院医学与健康科技创新工程重大协同创新项目

Clinical analysis of 51 female children with condyloma acuminatum

  • Received:2017-09-22 Revised:2018-03-12 Online:2018-05-15 Published:2018-05-02
  • Supported by:
    Natural Science Foundation of Jiangsu Province of China;CAMS Innovation Fund for Medical Sciences

摘要: 目的 分析尖锐湿疣女童患者的临床特点及治疗转归。方法 门诊收集12岁以下女性尖锐湿疣患者,采用问卷调查法询问病史并体检,PCR法检测人乳头瘤病毒(HPV)分型。采用描述性统计法统计高危因素、皮损情况、HPV检查结果,记录激光和光动力治疗次数等信息。结果 共收集51例12岁以下女童尖锐湿疣,年龄和病程[M(P25 ~ P75)]分别为3(2 ~ 5)岁、6(4 ~ 8)个月。其中,29例(56.9%)居住在城镇或郊区,16例(31.4%)在农村。2例患儿父母有明确的HPV感染史,12例(23.6%)平时常穿开裆裤,24例(47%)平素经常在服务场所洗浴,仅1例有明确的被性侵史。39例(76.5%)以肛周皮损为主,大菜花状皮损均发生在肛周。35例接受脱落细胞HPV检测,阳性率71.4%,阳性者全部为低危型(6/11型)。治疗过程中5例失访,剩余46例激光治疗次数中位数为2(P25 ~ P75,1 ~ 4)次,光动力治疗次数中位数为3(P25 ~ P75,3 ~ 4)次。治疗期[M(P25 ~ P75)]为4(2 ~ 6)个月,5例失访,其余46例均治愈,治愈率90.2%。结论 女童尖锐湿疣感染源可能以环境为主,最易累及肛周。激光和光动力治疗预后良好。

关键词: 尖锐湿疣, 儿童, 皮肤表现, 治疗结果

Abstract: Huang Dan, Ju Mei, Chang Baozhu, Chen Xu, Zhang Xiaohua, Zhu Yan, Zhou Ya′nan, Xu Nan, Chen Kun, Gu Heng Department of Physical Therapy, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China Corresponding authors: Chen Kun, Email: kunchen181@aliyun.com; Gu Heng, Email: doctor_guheng@hotmail.com 【Abstract】 Objective To analyze clinical features and treatment outcomes of female children with condyloma acuminatum. Methods Female outpatients with condyloma acuminatum aged less than 12 years were enrolled into this study. Through a questionnaire survey, medical histories were collected, and a physical examination was performed in these patients. Polymerase chain reaction (PCR) was conducted to determine the genotypes of human papillomavirus (HPV). Descriptive statistical methods were used to identify high risk factors for condyloma acuminatum, manifestations of skin lesions, and results of HPV test. The number of sessions of laser therapy and photodynamic therapy was also recorded. Results A total of 51 female children aged under 12 years with a diagnosis of condyloma acuminatum were enrolled into this study. Their median age and course of disease (M [P25 - P75]) were 3 (2 - 5) years and 6 (4 - 8) months respectively. Of the 51 patients, 29(56.9%) lived in the small towns or suburb of a city, and 16 (31.4%) lived in the rural areas. Only 2 children′s parents had a definite HPV infection history. Twelve children (23.6%) usually wore open-seat pants, 24 (47%) often took a bath in public bath houses, and only 1 child had a definite history of sexual assault. Among these patients, 39 (76.5%) mainly had perianal skin lesions, and all cauliflower-like lesions occurred on the perianal area. A total of 35 patients underwent the HPV test in the exfoliated cells. The positive rate of HPV was 71.4%, and all the HPV-positive patients were infected by low-risk HPV types (HPV6/11). During the treatment, 5 patients were lost to follow-up. In the remaining 46 patients, the median number of sessions of laser therapy and photodynamic therapy was 2 (1 - 4) and 3 (3 - 4)respectively. The median course of treatment was 4 (2 - 6)months. After the treatment, all the remaining 46 patients were cured with a recovery rate of 90.2%(46/51). Conclusions In these female children with condyloma acuminatum, the source of infection may maninly come from the environment, and skin lesions mostly occur on the perianal area. The prognosis is good after laser and photodynamic therapy.

Key words: Condylomata acuminata, Child, Skin manifestations, Treatment outcome