肿瘤坏死因子α拮抗剂治疗别嘌醇所致药疹后重新发热：药疹未控制？

doi:10.3760/cma.j.issn.0412-4030.2017.12.015

中华皮肤科杂志 ›› 2017, Vol. 50 ›› Issue (12): 920-921.doi: 10.3760/cma.j.issn.0412-4030.2017.12.015

肿瘤坏死因子α拮抗剂治疗别嘌醇所致药疹后重新发热：药疹未控制？

闫志华李施清施辛苏玉华经晶李纪兵张婷徐丰谈星陈玲玲

215011 苏州市第七人民医院皮肤科（闫志华）；南通大学杏林学院（李施清）；苏州大学附属第二医院皮肤科（施辛、苏玉华、经晶）；苏州大学附属儿童医院皮肤科（李纪兵、张婷）；苏州市中西医结合医院皮肤科（徐丰）；常熟市第一人民医院皮肤科（谈星）；苏州市立医院本部皮肤科（陈玲玲）

收稿日期:2017-02-03 修回日期:2017-03-29 出版日期:2017-12-15 发布日期:2017-11-30
通讯作者: 苏玉华 E-mail:su84088@163.com

Recurrence of fever after the treatment with tumor necrosis factor-α antagonist in a patient with allopurinol?induced drug eruption: is it attributed to uncontrolled drug eruption?

Yan Zhihua, Li Shiqing, Shi Xin, Su Yuhua, Jing Jing, Li Jibing, Zhang Ting, Xu Feng, Tan Xing, Chen Lingling

Received:2017-02-03 Revised:2017-03-29 Online:2017-12-15 Published:2017-11-30
Contact: yuhua SU E-mail:su84088@163.com

摘要/Abstract

摘要： 别嘌醇是引起重症药疹的首要致敏药物之一［1］。文献报道［2］约2%应用别嘌醇的患者可发生轻度药疹，0.1%～0.4%可发生重症药疹，死亡率20%～25%。我们在用肿瘤坏死因子α（TNF?α）拮抗剂益赛普治疗1例别嘌醇所致重症药疹时，患者退热后再次发热，经与药疹控制不良、药物热、伴嗜酸粒细胞增多和系统症状的药疹（DRESS）双峰热、病毒、细菌、免疫、肿瘤等鉴别诊断，最终确诊发热为痛风急性发作所致……

闫志华李施清施辛苏玉华经晶李纪兵张婷徐丰谈星陈玲玲. 肿瘤坏死因子α拮抗剂治疗别嘌醇所致药疹后重新发热：药疹未控制？[J]. 中华皮肤科杂志, 2017, 50(12): 920-921.

Yan Zhihua, Li Shiqing, Shi Xin, Su Yuhua, Jing Jing, Li Jibing, Zhang Ting, Xu Feng, Tan Xing, Chen Lingling. Recurrence of fever after the treatment with tumor necrosis factor-α antagonist in a patient with allopurinol?induced drug eruption: is it attributed to uncontrolled drug eruption?[J]. Chinese Journal of Dermatology, 2017, 50(12): 920-921.

参考文献 7

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肿瘤坏死因子α拮抗剂治疗别嘌醇所致药疹后重新发热：药疹未控制？

Recurrence of fever after the treatment with tumor necrosis factor-α antagonist in a patient with allopurinol?induced drug eruption: is it attributed to uncontrolled drug eruption?

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