Abstract: Zhang Yunjie, Zou Xianbiao, Guo Xiaojuan, Lin Hui Department of Dermatology, First Affiliated Hospital of PLA General Hospital, Beijing 100048, China Corresponding author: Zou Xianbiao, Email: xbzou@126.com 【Abstract】 Objective To evaluate the application value of dermoscopy in the diagnosis of genital condyloma acuminatum （CA） in men. Methods A total of 122 warts from 66 male patients with suspected genital CA were firstly diagnosed by experienced dermatologists according to macroscopic morphological characteristics of lesions and clinical history of patients. Afterwards, the warts were examined and diagnosed by dermoscopy, and the two diagnosis results were compared with histopathological findings. Results Of 122 suspected warts, 100 were diagnosed as CA by naked?eye examination, 112 as CA by dermoscopy and 114 as CA by pathological examination. When histopathological findings served as the gold standard, dermoscopy had a sensitivity of 97.4% and a specificity of 87.5%, and naked?eye examination had a sensitivity of 87.7% and a specificity of 100%. Under dermoscopy, most male genital warts were pink （98/114, 86.0%） and papillary （98/114, 86.0%）, and had distinct vascular characteristics （107/114, 95.5%）, which mainly included pleomorphic vessels （102/114, 89.5%） and punctate vessels （98/114, 86.0%）. Conclusion CA has characteristic structures under dermoscopy, so dermoscopy can be used for the diagnosis of genital CA in men.