Abstract: Tan Chunhua, Gan Liqiang, Ni Sili, Luo Xiaoyan, Wang Hua Department of Dermatology, Children′s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China Corresponding authors: Wang Hua, Email: huawang63@hotmail.com; Gan Liqiang, Email: doctorglq@sina.com 【Abstract】 Objective To evaluate the clinical efficacy and adverse effect of dual?wavelength pulsed dye laser for the treatment of spider angioma in children, and to observe recurrence of spider angioma after treatment with it. Methods A dual?wavelength approach with 585?nm and 1 064?nm pulsed?dye lasers was used to treat 233 children with spider angioma, who were followed up for at least 6 months. Correlations of the clinical efficacy with disease duration, skin complexion, age, gender and so on were analyzed, and adverse reactions and recurrence were evaluated. Results The clinical efficacy of the dual?wavelength pulsed dye laser was good in the treatment of spider angioma in children, with the recovery rate and response rate being 87.1% and 100% respectively, and was negatively correlated with the disease duration. There was no significant difference in the clinical efficacy among children with different skin complexions, but treatment sessions for recovery increased in children with Fitzpatrick skin type Ⅳ compared with those with Fitzpatrick skin type Ⅲ. Additionally, no significant difference in the clinical efficacy was observed among children of different age and gender. After the laser treatment, purpura, blisters and swelling occurred instantly, hyperpigmentation and hypopigmentation occurred in a short?term period, and no obvious long?term adverse reactions were observed. Of 233 children, 21 （9.4%） experienced recurrence between 6 months and 2 years after the laser treatment, with a mean recurrence interval of 7.3 ± 3.4 months. Conclusion The dual?wavelength pulsed dye laser is effective and safe for the treatment of spider angioma, and can serve as the first?line therapeutic method for childhood spider angioma.