中华皮肤科杂志 ›› 2017, Vol. 50 ›› Issue (3): 186-189.

• 论著 • 上一篇    下一篇

自体培养黑素细胞移植治疗白癜风供皮区出现同形反应者的疗效及相关因素分析

黄骏1,2,章玲玲2,洪为松1,付丽芳3,蔚晓冬2,林福全1,许爱娥4   

  1. 1. 杭州市第三人民医院
    2. 浙江中医药大学附属杭州第三医院
    3. 杭州市第三人民医院皮肤科
    4. 安徽医科大学附属杭州市第三人民医院皮肤科
  • 收稿日期:2016-06-14 修回日期:2016-11-11 发布日期:2017-03-01
  • 通讯作者: 许爱娥 E-mail:xuaiehz@msn.com
  • 基金资助:
    国家自然科学基金;国家自然科学基金;卫生部科学研究基金——浙江省医药卫生重大科技计划;杭州市重大科技创新项目

Therapeutic efficacy of autologous cultured melanocyte transplantation in the treatment of vitiligo among patients with isomorphic response at donor sites and its relevant factors

  • Received:2016-06-14 Revised:2016-11-11 Published:2017-03-01
  • Supported by:
    National Natural Science foundation of China;National Natural Science foundation of China

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摘要： 目的 分析供皮区出现同形反应的白癜风患者自体培养黑素细胞移植疗效及相关因素。方法 自体培养黑素细胞移植治疗白癜风患者1 685例，6个月后观察供皮区同形反应与疗效及其他因素的相关性。结果 75例（4.5%）供皮区发生同形反应的白癜风患者痊愈（复色率 ≥ 90%）13例（17.3%），有效（复色率 ≥ 50%）23例（30.7%）；1 610例无同形反应组痊愈865例（53.7%），有效1 376例（85.5%），经Fisher确切概率法检验，P < 0.001。75例发生同形反应者中，稳定时间 > 48个月、年龄 ≤ 12岁、节段型白癜风、移植部位位于面颈和躯干、全身白斑总面积 ≤ 100 cm2者的痊愈率和有效率均分别高于稳定时间12 ~ 48个月、年龄 ≥ 18岁、非节段型白癜风、移植部位位于四肢及全身白斑总面积 > 100 cm2者，差异均有统计学意义（P < 0.05）。结论 自体培养黑素细胞移植治疗稳定期白癜风时，供皮区发生同形反应者的疗效较差，且疗效与白癜风稳定时间、年龄、白癜风型别、移植部位、全身白斑总面积有关。

Abstract: Huang Jun, Zhang Lingling, Hong Weisong, Fu Lifang, Wei Xiaodong, Lin Fuquan, Xu Aie Department of Dermatology, Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310009, China Corresponding author: Xu Aie, Email: xuaiehz@msn.com 【Abstract】 Objective To evaluate the therapeutic efficacy of transplantation of autologous cultured pure melanocytes （TACM） in the treatment of vitiligo among patients with isomorphic response at donor sites, and to analyze its relevant factors. Methods A total of 1 685 patients with vitiligo were subjected to TACM. After 6?month follow?up, correlations were evaluated between isomorphic response at donor sites and the therapeutic efficacy of TACM, and factors associated with the therapeutic efficacy were analyzed. Results Of the 1 685 patients subjected to TACM, 75 （4.5%） had isomorphic response at the donor site. Among 75 patients with isomorphic response, 13 （17.3%） achieved 90% - 100% repigmenta?tion, and 23 （30.7%） achieved 50% - 90% repigmentation. However, among the 1 610 patients without isomorphic response, 865 （53.7%） achieved 90% - 100% repigmentation, and 1 376 （85.5%） achieved 50% - 90% repigmentation. Fisher′s exact probability test showed that the recovery rate and response rate were both significantly lower in the patients with isomorphic response than those without （P < 0.001）. Among the 75 patients with isomorphic response, the recovery rate and response rate were significantly higher in patients with the duration of stable phase > 48 months than in those with the duration of stable phase being 12 - 48 months, in patients aged ≤ 12 years than in those aged ≥ 18 years, in patients with segmental vitiligo than in those with non?segmental vitiligo, in patients with the recipient site on the face and trunk than in those with the recipient site on the limb, as well as in patients with total area of depigmented lesions ≤ 100 cm2 than in those with total area of depigmented lesions > 100 cm2 （all P < 0.05）. Conclusion Patients with isomorphic response show poor response to TACM, which may be associated with the duration of stable phase, patients′ age, types of vitiligo, recipient sites and total area of depigmented lesions.

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黄骏 章玲玲 洪为松 付丽芳 蔚晓冬 林福全 许爱娥. 自体培养黑素细胞移植治疗白癜风供皮区出现同形反应者的疗效及相关因素分析[J]. 中华皮肤科杂志, 2017,50(3):186-189. doi: