外用糖皮质激素联合含抗菌肽保湿剂对湿疹的疗效观察

中华皮肤科杂志 ›› 2016, Vol. 49 ›› Issue (10): 733-736.

外用糖皮质激素联合含抗菌肽保湿剂对湿疹的疗效观察

李妍¹,徐薇²,李邻峰³

1. 首都医科大学附属北京友谊医院皮肤性病科
2. 北京友谊医院皮肤科
3. 首都医科大学附属北京友谊医院皮肤科

收稿日期:2016-04-07 修回日期:2016-04-18 出版日期:2016-10-15 发布日期:2016-09-30
通讯作者: 徐薇 E-mail:2403649155@qq.com

Efficacy of topical glucocorticoids combined with a moisturizer containing antimicrobial peptides in the treatment of eczema: a clinical observation

¹,

Received:2016-04-07 Revised:2016-04-18 Online:2016-10-15 Published:2016-09-30

摘要/Abstract

摘要：

目的探讨外用糖皮质激素联合含抗菌肽保湿剂治疗持续性局限性湿疹的疗效及安全性。方法将60例局限性湿疹患者分为两组，治疗1组外用芙清抗菌功能性敷料及丁酸氢化可的松乳膏，治疗2组外用芙清凝胶基质及丁酸氢化可的松乳膏，每日2次，疗程为2周。皮损痊愈者，每4周随访1次，随访至第14周；选取5例皮损局部临床可疑金黄色葡萄球菌（金葡菌）感染患者于治疗前和治疗第2周进行金葡菌培养，比较其治疗期间和治疗后效果。结果第1周，两组疗效有效率差异有统计学意义（χ2 = 5.455，P < 0.05）；第1、2周，治疗1组和治疗2组湿疹面积及严重度指数评分差异有统计学意义（均P < 0.05）。选取5例皮损局部临床可疑金葡菌感染患者于治疗前和治疗第2周进行金葡菌培养，其中治疗1组金葡菌培养阳性3例，治疗2组金葡菌培养阳性2例。治疗第2周，治疗1组全部转为阴性，治疗2组仍阳性。治疗2周后停药，痊愈患者继续随访至第14周时，治疗1组7例痊愈患者均未出现无效病例，而治疗2组5例痊愈患者中2例于第10周判为无效。结论芙清抗菌功能性敷料联合糖皮质激素软膏治疗局限性湿疹安全、有效，可用于临床。

Abstract:

Li Yan, Xu Wei, Li Linfeng Department of Dermatology and Venereology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Corresponding authors: Xu Wei, Email: 2403649155@qq.com; Li Linfeng, Email: zoonli@sina.com 【Abstract】 Objective To evaluate the clinical efficacy and safety of topical glucocorticoids combined with a moisturizer containing antimicrobial peptides in the treatment of persistent localized eczema. Methods A total of 60 patients with localized eczema were divided into 2 groups. Group 1 topically applied Fuqing gel （an antimicrobial dressing） and hydrocortisone butyrate cream twice a day for 2 weeks, and group 2 topically applied the vehicle of Fuqing gel and hydrocortisone butyrate cream twice a day for 2 weeks. Recovered patients were followed up once every 4 weeks for 12 weeks. Bacterial culture was performed for 5 patients with suspected local Staphylococcus. aureus infection, including 3 patients in group 1 and 2 in group 2, before and after the 2-week treatment. Therapeutic effects were evaluated and compared between the two groups. Results Compared with group 2, group 1 showed a signifi-cantly higher response rate after 1-week treatment （χ2 = 5.455, P < 0.05）, but significantly lower eczema area and severity index （EASI） scores after 1- and 2-week treatment （both P < 0.05）. Before the treatment, S. aureus was detected in all the 5 patients. After 2-week treatment, S. aureus was undetected in all the 3 patients in group 1, but was still detected in the other 2 patients in group 2. The treatment was rated as ineffective in none of 7 recovered patients in group 1 during the 12-week follow up, but in 2 of 5 recovered patients in group 2 at week 10. Conclusion Fuqing gel combined with glucocorticoid ointment is safe and effective for the treatment of localized eczema, and can be applied in clinic.

李妍徐薇李邻峰. 外用糖皮质激素联合含抗菌肽保湿剂对湿疹的疗效观察[J]. 中华皮肤科杂志, 2016, 49(10): 733-736.

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