复方甘草酸苷对皮肤斑贴试验的影响

中华皮肤科杂志 ›› 2016, Vol. 49 ›› Issue (6): 402-405.

复方甘草酸苷对皮肤斑贴试验的影响

郭焱¹,孙晓东²,³,施辛¹,刘润秋⁴,经晶¹,陈晶晶¹,沈悦⁵,俞翠萍¹,闫志华¹,⁵,陈小建¹,陈玲玲⁶

1. 苏州大学附属第二医院
2. 苏州大学附属第二医院皮肤科
3. 唐山市丰南区妇幼医院
4. 盐城市第一人民医院皮肤科
5.
6. 南京医科大学附属苏州医院

收稿日期:2015-11-27 修回日期:2015-12-17 发布日期:2016-05-31
通讯作者: 施辛 E-mail:shx9@163.com
基金资助:
苏州市科教兴卫青年基金

Effect of compound glycyrrhizin on skin patch test results

Received:2015-11-27 Revised:2015-12-17 Published:2016-05-31

摘要/Abstract

摘要：

目的探讨复方甘草酸苷制剂对皮肤斑贴试验的影响。方法选取皮肤斑贴试验镍阳性（++）或甲醛阳性（++）患者84例，分别给予复方甘草酸苷制剂中剂量干预（复方甘草酸苷片50 mg每天3次）和高剂量干预（复方甘草酸苷片75 mg每天3次）均2周后重复皮肤斑贴试验以及静脉途径干预（复方甘草酸苷注射液，60 ml/d）1周后重复皮肤斑贴试验。应用SPSS 19.0版软件进行秩和检验，从斑贴试验定性和反应程度两个角度分别进行统计学分析。结果中剂量干预完成研究81例患者，第2次斑贴试验时，66例++，13例+，2例+++，无阴性结果者。两次斑贴试验结果定性无变化；反应程度Z = -2.84，P = 0.005，差异有统计学意义。高剂量干预完成研究82例患者，第2次斑贴试验时，37例++，36例+，9例阴性。两次斑贴试验结果：定性Z = -3.000，P = 0.003；反应程度Z = -6.247，P = 0.000，差异均有统计学意义。静脉途径干预完成研究58例患者，第2次斑贴试验时，12例++，10例+，36例阴性。两次斑贴试验结果：定性Z = -6.000，P = 0.000；反应程度Z = -6.289，P = 0.000，差异均有统计学意义。结论复方甘草酸苷制剂口服高剂量和静脉途径应用时，对皮肤斑贴试验反应有明显抑制作用。建议做斑贴试验前应停此药2周。

Abstract:

Guo Yan, Sun Xiaodong, Shi Xin, Liu Runqiu, Jing Jing, Chen Jingjing, Shen Yue, Yu Cuiping, Yan Zhihua, Chen Xiaojian, Chen Lingling Department of Dermatology, Second Affiliated Hospital of Soochow University, Suzhou 215004, China （Guo Y ［current affiliation: Department of Dermatology, Yancheng Third People′s Hospital, Yancheng 350001, Jiangsu, China］, Sun XD［current affiliation: Department of Dermatology, Fengnan District Maternal and Child Health Care Hospital of Tangshan City, Tangshan 063300, Hebei, China］, Shi Xin, Liu RQ［current affiliation: Department of Dermatology, First People′s Hospital of Yancheng City, Yancheng 224005, Jiangsu, China］, Jing J, Chen JJ, Shen Y, Yu CP, Yan ZH［current affiliation: Department of Dermatology, High-Tech Zone Hospital, Second Affiliated Hospital of Soochow University, Suzhou 215151, China］）; Department of Dermatology, Suzhou Municipal Hospital, Suzhou 215006, China （Chen XJ, Chen LL） Corresponding authors: Shi Xin, Email: shx9@163.com; Chen Lingling, Email: chenlingling031@126.com 【Abstract】 Objective To evaluate the effect of compound glycyrrhizin on skin patch test results. Methods A total of 84 patients who showed moderate positive （++） patch test reactions to nickel or formaldehyde were enrolled into this study. After the baseline patch tests, patients administrated 50 mg of compound glycyrrhizin tablets thrice a day for 2 weeks （middle-dose compound glycyrrhizin intervention）, then 70 mg of compound glycyrrhizin tablets thrice a day for 2 weeks （high-dose compound glycyrrhizin intervention）, and finally received intravenous injection of compound glycyrrhizin 60 ml once a day for 1 week （intravenous injection intervention）. Skin patch tests were conducted after each intervention. The results of skin patch tests were evaluated qualitatively and quantitatively. Statistical analysis was carried out by using the Wilcoxon rank sum test with the SPSS 19.0 software. Results Totally, 81 patients completed the middle-dose compound glycyrrhizin intervention trial, of whom, 66 were moderate positive （++）, 13 mild positive （+）, and 2 strong positive （+++） for skin patch tests following the trial, and no patient was negative. Significant differences were observed in the degree of reactivity （Z = -2.84, P = 0.005）, but not in qualitative results between the baseline and first post-intervention SPTs. Among 82 patients who completed the high-dose compound glycyrrhizin intervention, 37 were moderate positive （++）, 36 mild positive （+）, and 9 negative for the second post-intervention skin patch tests, with significant differences in qualitative results （Z = -3.000, P = 0.003） and degree of reactivity （Z = -6.247, P = 0.000） between the baseline and second post-intervention SPTs. Finally, 58 patients completed the intravenous injection intervention, of whom, 12 were moderate positive （++）, 10 mild positive （+）, and 36 negative for the post-intervention patch tests, with significant differences in qualitative results （Z = -6.000, P = 0.000） and the degree of reactivity （Z = -6.289, P = 0.000） between the baseline and third post-intervention SPTs. Conclusion Both high-dose oral compound glycyrrhizin and intravenous compound glycyrrhizin could evidently suppress skin patch test reactions, and compound glycyrrhizin is recommended to be withdrawn 2 weeks before skin patch tests.

郭焱孙晓东施辛刘润秋经晶陈晶晶沈悦俞翠萍闫志华陈小建陈玲玲. 复方甘草酸苷对皮肤斑贴试验的影响[J]. 中华皮肤科杂志, 2016,49(6):402-405. doi:

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