抗高血压药引起药疹的文献分析

摘要/Abstract

摘要： 抗高血压药种类繁多，结构复杂，常用的有利尿剂、钙离子拮抗剂、血管紧张素转化酶抑制剂、血管紧张素Ⅱ受体阻滞剂、β受体阻滞剂5大类，可引起各种不同类型的药疹。通过文献回顾，对抗高血压药引起的血管性水肿、红斑狼疮样、银屑病样、湿疹样、疱疹样、扁平苔藓样等药疹的临床特征、发病机制、治疗及转归进行归纳总结，实现抗高血压药引起药疹的早发现、早诊断、早停药、早治疗，并为抗高血压药引起的药疹的临床和基础研究提供信息和思路。

Abstract: Su Huichun, Yao Xu, Wang Baoxi Department of Allergy and Rheumatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China （the current affiliation of the third author was Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China） Corresponding authors: Yao Xu, Email: dryao_xu@126.com; Wang Baoxi, Email: wangbx@ncstdlc.org 【Abstract】 There are various kinds of antihypertensive agents with complex chemical structures. Common antihypertensive agents are divided into 5 classes, including diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, angiotensin Ⅱ receptor blockers and β-blockers, and can cause various types of drug eruptions. This review summarizes clinical characteristics, possible pathogenesis, treatment and consequences of antihypertensive agent-induced drug eruptions, including angioedema, and lupus erythematosus-like, psoriasis-like, eczematoid, herpetiform or lichen planus-like drug eruptions, in hope to facilitate their early detection, diagnosis and treatment, and to provide information and ideas for clinical and basic researches into them.

苏惠春姚煦王宝玺. 抗高血压药引起药疹的文献分析[J]. 中华皮肤科杂志, 2016, 49(3): 219-222.doi:

SU HuiChun WHANG Baoxi. Antihypertensive agent-induced drug eruptions: a literature review[J]. Chinese Journal of Dermatology, 2016, 49(3): 219-222.doi:

参考文献 31

［1］	Alencar RC, Cobas RA, Gomes MB. Allergic reaction related to ramipril use: a case report［J］. Diabetol Metab Syndr, 2010, 2: 4. DOI: 10.1186/1758⁃5996⁃2⁃4.
［2］	王冰丽. 卡托普利致剥脱性皮炎型［J］. 山东医药, 2007, 47（28）: 63. DOI: 10.3969/j.issn.1002⁃266X.2007.28.100.
	Wang BL. Exanthematous drug eruption due to captopril［J］. Shandong Med J, 2007, 47（28）: 63. DOI: 10.3969/j.issn.1002⁃266X.2007.
［3］	陈向前, 刘向农. 口服卡托普利致重症药疹合并药物性肝炎1例［J］. 福建医药杂志, 2004, 1（26）: 162. DOI: 10.3969/j.issn.1002⁃2600.2004.01.148.
	Chen XQ, Liu XN. A case of serious drug eruptions with hepatitis due to oral captopril［J］. Fujian Med J, 2004, 1（26）: 162. DOI: 10.3969/j.issn.1002⁃2600.2004.01.148.
［4］	Ozturk G, Turk BG, Senturk B, et al. Exanthematous drug eruption due to valsartan［J］. Cutan Ocul Toxicol, 2012, 31（4）: 335⁃337. DOI:10.3109/15569527.2011.647179.
［5］	Fessa C, Lim P, Kossard S, et al. Lichen planus⁃like drug eruptions due to beta⁃blockers: a case report and literature review［J］. Am J Clin Dermatol, 2012, 13（6）: 417⁃421. DOI: 10.2165/11634590⁃000000000⁃00000.
［6］	Joly P, Benoit⁃Corven C, Baricault S, et al. Chronic eczematous eruptions of the elderly are associated with chronic exposure to calcium channel blockers: results from a case⁃control study［J］. J Invest Dermatol, 2007, 127（12）: 2766⁃2771.
［7］	陈颖, 刘茁, 计雄飞, 等. 尼群地平引起大疱性表皮松解型药疹1例［J］. 临床皮肤科杂志, 2008（11）: 743. DOI: 10.3969/j.issn.1000⁃4963.2008.11.026.
	Chen Y, Liu Z, Ji XF, et al. A case of drug eruption （bullous epidermolysis type） induced by nitrendipine［J］. J Clin Dermatol, 2008（11）： 743. DOI: 10.3969/j.issn.1000⁃4963.2008.11.026.
［8］	Rasmussen E, Mey K, Bygum A. Angiotensin⁃converting enzyme inhibitor⁃induced angioedema:a dangerous new epidemic［J］. Acta Derm Venereol, 2014, 94（3）: 260⁃264. DOI: 10.2340/00015555⁃1760.
［9］	Powell RJ, Leech SC, Till S, et al. BSACI guideline for the management of chronic urticaria and angioedema［J］. Clin Exp Allergy, 2015, 45（3）: 547⁃565. DOI: 10.1111/cea.12494.
［10］	Cilia LCA, Carter AM, Rice GI, et al. A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor⁃induced angioedema［J］. Hum Mutat, 2011, 32（11）: 1326⁃1331. DOI: 10.1002/humu.21579.
［11］	Basavaraj KH, Ashok NM, Rashmi R, et al. The role of drugs in the induction and/or exacerbation of psoriasis［J］. Int J Dermatol, 2010, 49（12）: 1351⁃1361. DOI: 10.1111/j.1365⁃4632.2010.04570.x.
［12］	Gin A, Gin D, Sinclair R. Metoprolol⁃induced psoriatic nail disease［J］. Australas J Dermatol, 2013, 54（1）: 59⁃60. DOI: 10.1111/j.1440⁃0960.2012.00916.x.
［13］	Kim GK, Del RJ. Drug⁃provoked psoriasis: is it drug induced or drug aggravated?: understanding pathophysiology and clinical relevance［J］. J Clin Aesthet Dermatol, 2010, 3（1）: 32⁃38.
［14］	Wu S, Han J, Li W, et al. Hypertension, antihypertensive medi⁃cation use, and risk of psoriasis［J］. JAMA Dermatol, 2014, 150（9）: 957⁃963. DOI: 10.1001/jamadermatol.2013.9957.
［15］	Vena GA, Cassano N, Coco V, et al. Eczematous reactions due to angiotensin⁃converting enzyme inhibitors or angiotensin II receptor blockers［J］. Immunopharmacol Immunotoxicol, 2013, 35（3）: 447⁃450. DOI: 10.3109/08923973.2013.797992.
［16］	Landmesser U, Drexler H. Effect of angiotensin II type 1 receptor antagonism on endothelial function: role of bradykinin and nitric oxide ［J］. J Hypertens Suppl, 2006, 24（1）: S39⁃S43. DOI: 10.1097/01.hjh.0000220405.38622.23.
［17］	Gruen AB, Zhou J, Morton KA, et al. Photodegraded nifedipine stimulates uptake and retention of iron in human epidermal keratinocytes ［J］. J Invest Dermatol, 2001, 116（5）: 774⁃777.
［18］	Kanjanabuch P, Arporniem S, Thamrat S, et al. Mucous membrane pemphigoid in a patient with hypertension treated with atenolol: a case report［J］. J Med Case Rep, 2012, 6（10）: 373. DOI: 10.1186/1752⁃1947⁃6⁃373.
［19］	Stavropoulos PG, Soura E, Antoniou C. Drug⁃induced pemphigoid: a review of the literature［J］. J Eur Acad Dermatol Venereol, 2014, 28（9）:1133⁃1140. DOI: 10.1111/jdv.12366.
［20］	Baricevic M, Mravak Stipetic M, Situm M, et al. Oral bullous eruption after taking lisinopril⁃case report and literature review［J］. Wien Klin Wochenschr, 2013, 125（13⁃14）: 408⁃411. DOI: 10.1007/s00508⁃013⁃0382⁃7.
［21］	Adriano AR, Gomes NA, Hamester GR, et al. Pemphigus vegetans induced by use of enalapril［J］. An Bras Dermatol, 2011, 86（6）: 1197⁃1200.
［22］	Bae YI, Yun SJ, Lee SC, et al. Pemphigus foliaceus induced by an angiotensin II receptor blocker［J］. Clin Exp Dermatol, 2008, 33（6）: 721⁃723. DOI: 10.1111/j.1365⁃2230.2008.02857.x.
［23］	GangeRW, JonesEW. Bullous lichen planus caused by labetalol［J］. Br Med J, 1978, 1（6116）: 816⁃817.
［24］	Staughton R, Sutton R, Farrell M. beta⁃Blockers, autoimmunity, and rashes［J］. Lancet, 1980, 2（8194）: 581.
［25］	Marzano A, Vezzoli P, Crosti C. Drug⁃induced lupus: an update on its dermatologic aspects［J］. Lupus, 2009, 18（11）: 935⁃940. DOI: 10.1177/0961203309106176.
［26］	Marzano AV, Lazzari R, Polloni I, et al. Drug⁃induced subacute cutaneous lupus erythematosus: evidence for differences from its idiopathic counterpart［J］. Br J Dermatol, 2011, 65（2）: 335⁃341. DOI: 10.1111/j.1365⁃2133.2011.10397.x.
［27］	Sawada Y, Yoshiki R, Kawakami C, et al. Valsartan⁃induced drug eruption followed by CD30+ pesudolymphomatous eruption［J］. Acta Derm Venereol, 2010, 90（5）: 521⁃522. DOI: 10.2340/00015555⁃0695.
［28］	Kabashima R, Orimo H, Hino R, et al. CD30⁃positive T⁃cell pseudolymphoma induced by amlodipine［J］. J Eur Acad Dermatol Venereol, 2008, 22（12）: 1522⁃1524. DOI: 10.1111/j.1468⁃3083.2008.02671.x.
［29］	Chan JC, Yap DY, Yeung CK. Hydralazine⁃induced toxic epidermal necrolysis in a patient on continuous ambulatory peritoneal dialysis［J］. J Clin Pharm Ther, 2014, 39（3）: 322⁃324. DOI: 10.1111/jcpt.12141.
［30］	Barcik K, Protas⁃Drozd F, Weiss⁃Rostkowska W, et al. Acute generalised exanthematosus pustulosis （AGEP） due to diltiazem--a case report［J］. Kardiol Pol, 2009, 67（8）: 887⁃891.
［31］	Chaabane A, Fadhl NB, Chadly Z, et al. Captopril⁃induced DRESS: first reported case confirmed by patch test［J］. Dermatitis, 2013, 24（5）: 255⁃257. DOI: 10.1097/DER.0b013e3182a5d86d.