Abstract:

Wu Yan*, Wang Peng, Wei Chunbo, Zhang Liang, Yan Huiwen, Lun Wenhui, Li Xingwang. *Department of Dermatology and Venereology, Beijing Ditan Hospital, Capital Medical Univesity, Beijing 100015, China Corresponding author: Lun Wenhui, Email: lunwenhui@163.com 【Abstract】 Objective To compare the prevalence and genotype distribution of human papillomavirus （HPV） between human immunodeficiency virus （HIV）-positive and -negative populations. Methods Patients with condyloma acuminatum or persons who recently had sexual contact with patients with condyloma acuminatum were enrolled into this study, and classified into HIV-positive group （n = 62） and HIV-negative group（n = 2 716）. GeneChip analysis was performed to detect HPV and determine HPV genotypes in mucocutaneous samples collected from the external genitalia of these subjects. Statistical analysis was carried out by chi-square test using the SPSS software version 19.0. Results The prevalence rates of HPV infection, high-risk HPV types and low-risk HPV types were significantly higher in HIV-positive persons than in HIV-negative persons （74.19% （46/62） vs. 42.30% （1 149/2 716）, 67.74% （42/62） vs. 29.57% （803/2 716）, 58.06% （36/62） vs. 24.71% （671/2 716）, respectively, all P < 0.01）. The detection rate of HPV was also increased in HIV-positive men compared with HIV-negative men （92.11% （35/38） vs. 37.38% （382/1 022）, χ2 = 45.98, P < 0.01）. Although the top three genotypes of low-risk HPV were types 6, 43 and 11 in both HIV-positive and -negative groups, the prevalence rate of HPV 6 was 37.10% （23/62） in HIV-positive group, but only 11.12% （302/2 716） in HIV-negative group. The top five genotypes of high-risk HPV were types 16 （22.58%, 14/62）, 52, 66, 58 and 18 in HIV-positive group, and types 16 （7.77%, 211/2716）, 58, 56, 66 and 52 in HIV-negative group. Coinfections with multiple HPV subtypes were common in both groups, and the number of concurrent HPV genotypes was as high as 8 in HIV-positive group, and 9 in HIV-negative group. The prevalence rate of coinfections with three or more HPV genotypes in HIV-positive group was significantly higher than that in HIV-negative group （65.21% （30/46） vs. 16.71% （192/1 149））. Conclusions Compared with HIV-negative populations, HIV-positive populations show elevated prevalence of HPV infection, high-risk HPV genotypes and low-risk HPV genotypes. Moreover, the prevalence of HPV is higher in HIV-positive men than in HIV-negative men. These findings are worthy of further attention in clinic.