关键词: 皮肤溃疡, 成纤维细胞生长因子1, 负压治疗

Abstract: Li Gang, Liu Zijian, Li Xiaobing. Department of Plastic and Burn Surgery, Tianjin First Center Hospital, Tianjin 300192, China Corresponding author: Liu Zijian, Email: liuzijian660629@sina.com 【Abstract】 Objective To evaluate the clinical efficacy of continuous irrigation with recombinant human acid fibroblast growth factor （rh-aFGF） combined with negative-pressure drainage in the treatment of refractory skin ulcer. Methods A clinical trial was performed from January 2010 to December 2012. Sixty patients with refractory skin ulcer were randomly and equally classified into three groups: group A receiving continuous irrigation with rh-aFGF combined with negative-pressure drainage, group B receiving irrigation of raw surfaces with rh-aFGF followed by bandaging after debridement, group C receiving covering of raw surfaces with Vaseline gauze and absorbent gauze followed by bandaging after debridement. Dressings were changed once daily in every group. The treatment lasted 21 days. The efficacy of these regimens was evaluated on day 7, 14 and 21. Results At the above time points for observation, both the granulation and epithelium tissues of ulcers grew well in group A, with a decrease in the volume of wounds and area of exposed deep tissues. There was a significant increase in the cure rate and reduction rate of wound volume in group A compared with the other two groups （all P < 0.01）. Conclusion Refractory dermal ulcer can be treated with continuous irrigation with rh-aFGF combined with negative-pressure drainage.

Key words: Skin ulcer, Fibroblast growth factor 1, Negative-pressure drainage