S100阳性不典型幼年性黄色肉芽肿一例随访观察并文献复习

中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (4): 247-250.

S100阳性不典型幼年性黄色肉芽肿一例随访观察并文献复习

王彦红¹,沈宏²,许爱娥³

1. 杭州市第三人民医院
2. 杭州市第三人民医院皮肤科
3. 安徽医科大学附属杭州市第三人民医院皮肤科

收稿日期:2013-07-04 修回日期:2014-01-16 出版日期:2014-04-15 发布日期:2014-04-01
通讯作者: 沈宏 E-mail:shenhongsh@medmail.com.cn

A case of S100-positive atypical juvenile xanthogranuloma: a longitudinal observation and review of the literature

Received:2013-07-04 Revised:2014-01-16 Online:2014-04-15 Published:2014-04-01

摘要/Abstract

摘要： 【摘要】患者男，3岁，因躯干多发棕黄色丘疹3个月就诊。皮损组织病理学检查，见真皮较多单一核组织细胞、嗜酸性粒细胞及少量淋巴细胞浸润。免疫组化示S100阳性、CD1a部分阳性、CD68阳性。其后原发皮疹颜色渐变暗，部分变平消退，留色素沉着，但仍有新发皮疹。4个月后第2次组织病理学检查显示，除组织细胞、嗜酸性粒细胞外，真皮尚可见少许多核巨细胞。免疫组化示组织细胞S100阴性、CD1a阴性、CD68 阳性。诊断：幼年性黄色肉芽肿。

关键词: 黄肉芽肿，青少年性, S100蛋白质类, 抗原，CD1

Abstract: Wang Yanhong, Shen Hong, Xu Aie. Department of Dermatology, Third People′s Hospital of Hangzhou, Hangzhou 310009, China Corresponding anthor: Shen Hong, Email: shenhongsh@medmail.com.cn 【Abstract】 A 3-year-old boy presented with a 3-month history of brown-yellow papules scattered on the trunk. The first skin biopsy showed a dermal infiltrate of many mononuclear histiocytes, eosinophilic granulocytes and a small number of lymphocytes. Immunohistochemical examination of the lesions demonstrated positive reactions with anti-CD68, -S100 and -CD1a （partial） antibodies. After the biopsy, the skin lesions gradually turned dark and partially regressed leaving hyperpigmentation, but new lesions continuously appeared. Four months later, a second biopsy was performed, and showed a dermal infiltrate of histiocytes with eosinophilic granulocytes and a few multinucleated giant cells. Immunohistochemistry showed that the histiocytes stained positive for CD68, but negative for S100 and CD1a. Based on the above findings, the patient was diagnosed with juvenile xanthogranuloma.

Key words: Xanthogranuloma, juvenile, S100 proteins, Antigens, CD1

王彦红沈宏许爱娥. S100阳性不典型幼年性黄色肉芽肿一例随访观察并文献复习[J]. 中华皮肤科杂志, 2014, 47(4): 247-250.

参考文献

[1]Yamamoto Y，Kadota M，Nishimura Y.A case of S-100-positive juvenile xanthogranuloma: a longitudinal observation[J].Pediatr Dermatol, 2009, 26(4):475-476
[2] James WD，Berger TG，Elston DM.Andrews’Diseases of the Skin Clinical Dermatology. 10th ed. USA: Saunders，2006: 760.
[3]Kubota Y，Kiryu H，Nakayama J，et al.Histopathologic maturation of juvenile xanthogranuloma in a short period[J].Pediatr Dermatol, 2001, 18(2):127-130
[4]Janssen D，Harms D.Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry[J].Am J Surg Pathol., 2005, 29(1):21-28
[5]Kraus MD，Haley JC，Ruiz R，et al.Juvenile’ xanthogranuloma: an immunophenotypic study with a reappraisal of histogenesis[J].Am J Dermatopathol, 2001, 23(2):104-111
[6]Chaudhry IA，Al-Jishi Z，Shamsi FA，et al.Juvenile xanthogranuloma of the corneoscleral limbus: case report and review of the literature[J].Surv Ophthalmol, 2004, 49(6):608-614
[7]Hermel M，Donner A，Remky A.New treatment option for adult-onset limbal xanthogranuloma[J].Cornea, 2010, 29(1):113-116
[8]Kanoff JM，Colby K，Jakobiec FA.Incipient corneoscleral xanthogranuloma with S-100 positivity in a teenager[J].Cornea, 2010, 29(6):688-690
[9]廖松林，柳剑英.皮肤组织细胞增生性疾病的几个问题一[J].诊断病理学杂志, 2003, 10(4):205-206
[10]Zelger B，Cerio R.Xanthogranuloma is the archetype of non-Langerhans cell histiocytoses[J].Br J Dermatol, 2001, 145(2):369-371
[11]Weitzman S，JaffeR.Uncommon histiocytic disorders: the non-langerhans cell histiocytoses[J].Pediatr Blood Cancer, 2005, 45(3):256-264
[12]Glavin FL，Chhatwall H，Karimi K.Progressive nodular histiocytosis: a case report with literature review，and discussion of differential diagnosis and classi?cation[J].J Cutan Pathol, 2009, 36(12):1286-1292
[13] Rodriguez-Jurado R，Duran-McKinster C，Ruiz-Maldonado R..Benign cephalic histiocytosis progressing into juvenile xanthogranuloma:a non-Langerhans cell histiocytosis transforming under the influence of a virus? Am J Dermatopathol，2000，22(1): 70–74.
[14] Sidwell RU，Francis N，Slater DN，et al.Is disseminated juvenile xanthogranulomatosis benign cephalic histiocytosis? Pediatr Dermatol， 2005，22(1): 40-43.
[15]Hoeger PH，Diaz C，Malone M，et al.Juvenile xanthogranuloma as a sequel to Langerhans cell histiocytosis: a report of three cases[J].Clin Exp Dermatol, 2001, 26(5):391-394
[16]Shani-Adir A，Chou P，Morgan E，et al.A child with both Langerhans and non-Langerhans cell histiocytosis[J].Pediatr Dermatol, 2002, 19(5):419-220
[17]Patrizi A，Neri I，Bianchi F，et al.Langerhans cell histiocytosis and juvenile xanthogranuloma[J].Two case reports. Dermatology, 2004, 209(1):57-61
[18]Tran DT，Wolgamot GM，Olerud J，et al.An 'eruptive' variant of juvenile xanthogranuloma associated with langerhans cell histiocytosis[J].J Cutan Pathol., 2008, 35(Suppl 1):50-54
[19]Yu H，Kong J，Gu Y，et al.A child with coexistent juvenile xanthogranuloma and Langerhans cell histiocytosis[J].J Am Acad Dermatol, 2010, 62(2):329-332