中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (6): 431-432.

• 研究报道 • 上一篇    下一篇

蕈样肉芽肿在反射式共聚焦显微镜下的特征

李伟1,戴辉2,黎钊3,许爱娥4   

  1. 1. 安徽医科大学附属杭州临床学院
    2. 杭州市第三人民医院皮肤科
    3. 浙江中医药大学附属杭州第三医院
    4. 安徽医科大学附属杭州市第三人民医院皮肤科
  • 收稿日期:2012-06-04 修回日期:2012-07-17 出版日期:2013-06-15 发布日期:2013-06-01
  • 通讯作者: 许爱娥 E-mail:xuaiehz@msn.com

Evaluation of mycosis fungoides with reflectance confocal microscopy

Wei LI1,hui dai1, 1,   

  • Received:2012-06-04 Revised:2012-07-17 Online:2013-06-15 Published:2013-06-01

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摘要： 【摘要】 目的 探讨临床上皮损表现为红斑鳞屑的蕈样肉芽肿在反射式共聚焦显微镜（RCM）下的特征。方法　2011年6月至2012年5月皮肤科门诊的收集蕈样肉芽肿患者6例，年龄7 ～ 73岁，病程1 ~ 5年；男4例，女2例；斑片期2例，斑块期3例，肿瘤期1例。均经组织病理和免疫组化及相关检查确诊。RCM观察6例蕈样肉芽肿患者各3处皮损，选取1处皮损行组织病理检查。 结果　发现角化过度，棘层混乱，基底层色素环折光减弱，表皮内可见散在分布的单个圆形或类圆形的高折光细胞，真皮乳头环内可见少许炎细胞浸润。少数可见低折光的，圆形至椭圆形的细胞聚集形成的一个囊泡样结构。这些RCM特征与其组织病理对照有较好的一致性。 结论　结合临床表现，RCM 可能作为蕈样肉芽肿的无创性辅助诊断方法。

关键词: 蕈样肉芽肿, 显微镜检查，共焦

Abstract: LI Wei *, DAI Hui, LI Zhao, XU Ai-e. *Department of Dermatology, Affiliated Hangzhou Clinical College, Anhui Medical University, Hangzhou 310009, China Corresponding author: XU Ai-e, Email: xuaiehz@msn.com 【Abstract】 Objective To investigate the reflectance confocal microscopy （RCM） features of mycosis fungoides （MF）. Methods Four male and two female patients with MF, who were aged 7 － 73 years with a clinical course of 1 － 5 years, were collected from June 2011 to May 2012 in the department of dermatology. Of the six patients, two were in patch stage, three in plaque stage, and one in tumor stage. All the cases were confirmed by histopathological, immunohistochemical and relevant examinations. For each patient, three lesions were selected and investigated using RCM, and one of the three lesions was subjected to histopathological examination. Results RCM features of MF included hyperkeratosis, disarray of honeycomb of stratum spinosum, reduced refractivity of dermal papillary rings, roundish or round scattered hyperrefractive cells in the epidermis, infiltration of a small quantity of inflammatory cells in the papillary dermis. Occasionally, some round to oval hyporefractive cells aggregated to form vesicle-like structures. These RCM features correlated well with histopathologic findings. Conclusion Combined with clinical manifestations, RCM may serve as a noninvasive auxiliary tool for the diagnosis of MF.

Key words: Mycosis Fungoides