中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (1): 24-25.

• 论著 • 上一篇    下一篇

肉桂醛体外抗真菌作用初探

席丽艳, 李鹤玉, 卢玉娟, 武庆科   

  1. 哈尔滨医科大学附属一院皮肤科
  • 收稿日期:1987-10-20 修回日期:1988-01-16 出版日期:1989-02-15 发布日期:1989-02-15

IN VITRO STUDY ON ANTIFUNGAL ACTIVITY OF CINNAMALDEHYDE

XI Li-Yan, Li He-Yu   

  1. The First Affiliated Hospital, Harbin Medical University
  • Received:1987-10-20 Revised:1988-01-16 Online:1989-02-15 Published:1989-02-15

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摘要： 本文测定肉桂醛对部分常见真菌的体外抗菌谱.发现其对8种酵母及酵母样真菌的MIC值范围为1.95-62.51μg/ml,以克柔假丝酵母和热带假丝酵母最敏感;对皮癣菌及深部真菌的M工C范围为7.82-125.00μg/ml,以紫色癣菌最敏感.同时作了药物对10株白念菌的时间抑菌动态观察,抑菌曲线表明孵育8小时时,出现抑菌最低点.采用酮康唑对照,发现该药的MIC值普遍较酮康唑高.扫描和透射电镜也证实该药对白念菌、石膏毛癣菌和申克氏孢子丝菌有较强破坏作用,见菌外形改变及细胞壁破损.

Abstract: This paper studies antifungal activity of Cinnamaldehyde against some common fungi and compares with that of Ketoconasolc.The results showed the MIC of Cinnamaldehyde against yeast and yeast-like fungi ranged from 1.95 to 62.50μg/ml,C.krusei and C.tropicalis were the most sensitive fungi to this dnig.The MIC against dermatomyces and deep fungi ranged from 7.82 to 125.00μg/ml,and T.viloacettm was the most sensitive strain.Time-inhibition of this drug against 10 isolates of C.albicans from different patients was also studied.The lowest antifungal point occurred 8 hours after incubation.SEM and TEM examination demonstrated morphologic change and cell wall impairment of C.albicans,T.mentagrophytes and S.schenckii after they were treated with Cinnamaldehyde.