中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (1): 8-11.

• 论著 • 上一篇    下一篇

变应性血管炎与免疫复合物的关系

何成雄, 靳培英, 徐文严   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1987-09-14 修回日期:1987-12-01 出版日期:1989-02-15 发布日期:1989-02-15

RELATIONSHIP BETWEEN IMMUNE COMPLEXES AND ALLERGIC VASCULITIS

HE Cheng-Xiong, JIN Pei-Ying   

  1. Institute of Dermatology, Chinese Academy of Medical Scientces, Nanjing
  • Received:1987-09-14 Revised:1987-12-01 Online:1989-02-15 Published:1989-02-15

PDF (PC)

494

赞

摘要： 本文采用PPUPA检测了40名HC,50例AAV和23例RAV的CIC浓度,方差分析Q检验发现AAV的CIC浓度高于HC和RAV,具有非常显著意义(P值均小于0.01),HC与RAV之间CIC浓度差别无显著意义(P>0.05).采用PEG沉淀-NS解离一单向免疫扩散试验分析了40名HC,49例AAV和23例RAV的CIC中的某些成份.采用DIF检测了43例AAV早期皮损的血管免疫反应物,其中23例阳性.用配对计数资料X2检验发现,同一AAv患者的CIC中IgA,C3与DIF结果中IgA,C3的差别无显著意义(两者P值均大于0.05),CIC与DIF结果中的IgM差别具有非常显著意义(P<0.01),但没有一例CIC中IgM阴性而DIF结果中IgM阳性者.因此认为,CIG与DIF结果中的某些成份基本一致,血管免疫反应物可能来自CIC.本文的研究结果支持CIC在AV的发病机理中起主要作用,并指出,以PPUP人检测的CIC浓度可作为评价AV疗效及估计AV预后的指标.

Abstract: Polyethylene glycol precipitation-atravielet pliotometric assay (PPUPA) was employed to measure the concentration cf CIC in 40 healthy controls (HC),50 patients with acute allergic vasculitis (AAV) and 23 patients recovered from allergic vasculitis (RAV),and the concentration of CIC was compared with analysis of variance and Q test.The results showed that the value of CIC was significantly higher in AAV than that of HC and RAV (both P <0.01),and there was on significant difference between that of HC and RAV (P>0.05).By PEG precipitation-NS disolution-single radial immunodiffusion,some components in CIC were determined in 40 HC,49 AAV and 23 RVA.The early skin lesions of 43 paeients with AAV were examined by DIF,of them vascular immunoreactants were observed in 23 (53.5%).With p:fired enumeration data X2 test comparisons of the components in CIC with those observed in DIF showed that there were no significant differences of IgA and C3/C3c (both P >0.05),but there was significant disparity of IgM in CIC and DIF results (P<0.01).No patient without IgM in CIC had Ig1Z in DIF.It is appropriate to deduce that that some components in CIC are closely related to the vascular immunoreactants detected by DIF.The results of this study support the hypothesis that CIC probably plays a major sole in the pathogenesis of AV,and that the concentration of CIC measured by PPUPA may serve as an indicator for assessing the therapeutic effect and estimating the prognosis of AV.