薄荷醇在正常人皮肤增加曲安缩松的透皮生物利用度

中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (6): 375-376.

薄荷醇在正常人皮肤增加曲安缩松的透皮生物利用度

王宗锐, 吴宋夏, 冯仕苏, 吴跃进

广东头学院药理教研室, 广州 524023

出版日期:1992-12-15 发布日期:1992-12-15

Study on Bioavailability of Percutaneous Penetration of Tramcinolone Acetonide Enhanced by Menthol in Healthy Volunteers Skin

WANG Zhong-Rui, WU Song-Xin

Zhanjiang Medical College, Guangdong 524023

Online:1992-12-15 Published:1992-12-15

摘要/Abstract

摘要： 在健康志愿者前臂内侧皮肤进行的苍白试验表明,薄荷醉本身不引起皮肤苍白反应,但是明显增加曲安缩松所致的皮肤苍自反应.其增强作用具有剂量依赖关系,提示薄荷醉对曲安缩松有促进透皮的作用.

关键词: 薄荷醇, 曲安缩松, 透皮促进剂, 生物学效用

Abstract: The human skin blannching assay has been shown to be a reliable method to compare the bioavailability of topical corticosteroid formulations.The study concentrates on the inftuences of different concentrations of menthol on the bioavailability of percutaneaus penetration of triamcinolone acetonide with skin blanching assay in healthy volunteers.The results of the assay indicated that menthol enhanced the bioavailability of percucaneous penetration of triamcinolone acetonide significantly,and showed clear dose-dependent relationship.It is our conclusion that menthol is a perctttaneous penetration enhancer For triameinolone acetonide.

Key words: Triamcinplone, acetonide, Menthol Pereutaneous penetration enhancer, Biological availability

王宗锐, 吴宋夏, 冯仕苏, 吴跃进. 薄荷醇在正常人皮肤增加曲安缩松的透皮生物利用度[J]. 中华皮肤科杂志, 1992, 25(6): 375-376.

WANG Zhong-Rui, WU Song-Xin. Study on Bioavailability of Percutaneous Penetration of Tramcinolone Acetonide Enhanced by Menthol in Healthy Volunteers Skin[J]. Chinese Journal of Dermatology, 1992, 25(6): 375-376.