中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (6): 372-374.

• 论著 • 上一篇    下一篇

八种中药影响淋病奈瑟菌粘附的体外研究

吴喜光1, 王冰梅2, 蒲卓1, 罗庆录1, 丰少珍3   

  1. 1. 吉林医学院附属医院皮肤科, 吉林市 132011;
    2. 吉林医学院附属医院皮肤科微生物学教研室;
    2. 吉林医学院附属医院皮肤科进修医师
  • 收稿日期:1991-07-20 修回日期:1991-11-19 出版日期:1992-12-15 发布日期:1992-12-15

Study on the Effects of Eight Chinese Herbal Medicines on teh Adherence of N.Gonorrhoeae in Vitro

WU Xi-Guang1, WANG Bing-Mei2   

  1. The Affiliated Hospital Jilin Medical College, Jilin 132011
  • Received:1991-07-20 Revised:1991-11-19 Online:1992-12-15 Published:1992-12-15

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摘要： 选用8种不同单味中药分别预处理人尿道上皮细胞(UEC),淋病奈瑟菌(NG)以及尿道上皮细胞一淋病奈瑟菌(UEC-NG).观察中药对NG粘附UEC的影响情况.光镜下见草麻等5种中药处理的UEC表面粘附的NG数址明显减少,与白术等3种中药及无药对照相比均有差异.扫描电镜发现,UEC经草麻等中药预处理后,细胞表面光滑、细胞壁无皱缩及破损现象.实验结果表明:草薢、制大黄等中药可有改善宿主机体对NG的非特异性抗感染因素、抑制NG对UEC的粘附及避免细菌耐药发生等作用.本实验为筛选临床治疗淋病的中药提供了一种方法.

关键词: 药,中草, 淋病奈瑟菌

Abstract: Eight Chinese herbal medicines were individually used to pretrcat human ureEhral epithe- lial cells(UEC),strains of Neisseria gonorrhoeae(NG) and UEC-NG in vitro.The results shoGwd that under light micrnscope the number of gonococci ors UEC pretreaked 6y Dioscorca hypoglauca Palih,khcum ofhcinale Baill,Plautago asiatca L.,Ahcbia triioliata Koidz and Smilax alabra Roxb siginificantly decreased than those of otlser mrdiciues and the Control(P<0.01).Under SEM,the cells underwent Dirscorea hypoglrtuca Palib and so on pretrcatmeut showed no morphological chatigcs.It suggests that tltese Chinese herbal medicines probably play certain role in improving human resistance to N.gonarrhoeae,inhibiting rite attaclnnent of NG to,iost cells and avoiding resistant strains production.It also indicates that this experiment might provide a mvdtad for screening of the Chinese medicine im treating gondcoccal infections.

Key words: Drugs,Chinese, Herbal, Neisseria, gonorrhoeae