中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (1): 3-5.

• 论著 •    下一篇

丹参酮治疗痤疮及对皮脂和丙酸杆菌数的影响

周华, 沈永年, 吴绍熙   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1990-07-02 修回日期:1990-11-24 出版日期:1992-02-15 发布日期:1992-02-15

Double Blind Study on Tanahinone Versus Placebo in the Treatanent of Acne Vulgari and the Effects on Sebum Excretion Rate and Propionibacterium Acnes Counts

ZHOU Hua, SHEN Yong-Nian   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, 210042
  • Received:1990-07-02 Revised:1990-11-24 Online:1992-02-15 Published:1992-02-15

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摘要： 报告了口服丹参酮每日3g共6周双盲对照治疗炎症性寻常痤疮和治疗对皮脂滋出率(SER)及痤疮丙酸杆菌计数(PAC)的影响情况.结果丹参酮组疗效优2例,良9例,中5例,差3例.总有效率达84%,无明显副作用.安慰剂组19例中总有效率仅16%.丹参酮治疗组SER降低40%.PAC亦明显降低,两者降低并无相关性.提示丹参酮治疗痤疮机理可能通过:①抗雄激 素作用,降低皮脂产生,②抗痤疮丙酸杆菌作用,减轻由细菌代谢所加剧的炎症.

关键词: 痤疮, 丹参酮, 皮脂溢, 丙酸细菌属

Abstract: A double blind study was performed to evaluate the efficacy of oral Tanshinone, an ether extract from Radix salviae Multiorrhizae, in a dosage of 3g daily versus placebo for 6 weeks in the treatment of inflammatory acne vuigaris. The clinical effects of Tanshinone in 2 of the 19 patients were excellent, 8 were good, 5 were fair and 3 were poor, with a total efficacy up to 84% and without any untoward reaction.

Key words: Acne, Tanshinnone, Seborrhae, Propionibactrium