中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (4): 230-233.

• 论著 • 上一篇    下一篇

银屑病与HLA相关的研究

施燕, 马林, 王怀劬, 徐可愚, 邵长庚   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1989-01-05 修回日期:1989-09-22 出版日期:1990-08-15 发布日期:1990-08-15
  • 基金资助:
    中国科学院科学基金资助课题

Study of carrelation of psoriasis with HLA

SHI Yan, MA Lin   

  1. Institute of Dermatnlegy, Chinese Academy of Medical Sciences, Nanjing
  • Received:1989-01-05 Revised:1989-09-22 Online:1990-08-15 Published:1990-08-15

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摘要： 通过对17个银屑病多发家系及109例无血缘关系的银屑病患者HLA-A,B抗原的检测,发现A3、B13抗原频率显著升高,A11抗原频率显著下降.遗传特性分析提示银屑病既非显性也非隐性遗传,单倍型关联分析发现有3个和致病有关的单倍型,为A2-B13、A3-B13,A9-B5;单倍型分离分析进一步证实银屑病与HLA单倍型显著关联,Lods分析表明银屑病致病基因与HLA基因呈中等程度的连锁.HLA抗原与银屑病临床应用的分析显示对可疑银屑病患者进行A3、B13抗原检测有助于早期诊断.

Abstract: HLA-A, B antigens were determined in 17 families with more than one patient and 109 unrelated paoriatic patients, of Han Nationality, Jiangsu Province. Increased frequency of HLA-A3, B13 and decreased frequency of HLA-All were fated in paoriatic patients. Analysis of inheritance mode showed psoriasis is neither antosomal dominant nor autosomal recessirve.