中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (1): 31-33.

• 论著 • 上一篇    下一篇

HLA抗原与白癫风相关的群体研究

戴星, 靳培英, 马林, 曾慧明   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1988-09-26 出版日期:1990-02-15 发布日期:1990-02-15

ASSOCIATION OF HLA ANTIGENS WITH VITILIGO

DAI Xing, JIN Pel-Ying   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing
  • Received:1988-09-26 Online:1990-02-15 Published:1990-02-15

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摘要： 本文对100例江苏籍汉人白癫风患者进行了HLA-A、B位点的抗原检,其中泛发型40例、局限型30例、皮节型30例.结果发现白癫风与HLA-A2,HLA-A3关联.然而,不同临床型患者的HLA抗原频率并不一致,泛发型患者HLA-A2,HLA-A3抗原频率显著增高,并与HLA-A2,A3有关联,局限型仅与HLA-A3关联,皮节型患者未发现相关抗原,提示不同临床型白斑风的发病机理可能有所不同.

Abstract: The assoiciation of IiLA antigens with vitiligo is reported.HL.A-A,B typing was performed on 100 unrelated vitiligo paitents of Jiangsu Han nationality,inculding 40 patients with generalized vitiligo,30 with localized vitiiigo and 30 with segmental vitiligo.The results showed that vitiligo was associated with HLA-A2 and HLA-A3.However,the frequecies of HLA in the patients with different clinic types were not dicnticaI.The generalized type was found to be significantly associated with HLA-A2 and HLA-A3,the lcoalized type only associated with HLA-A3.No definite HLA antigen was found to be associated with the segmcrrtal type.The results suggest that the pathogensis of vitiligo of three types be different.