中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (1): 28-30.

• 论著 • 上一篇    下一篇

寻常型银屑病患者红细胞变形能力和膜ATP酶活性改变

潘卫利, 吴绍熙, 郭宁如, 吕桂霞   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1988-08-30 修回日期:1989-02-01 出版日期:1990-02-15 发布日期:1990-02-15

ALTERED DEFOPRMABILITY AND ATP-ase ANTIVITY OF ERYTHROCYTES IN PATIENTS WITH PSORIASIS

PAN Wei-Li, WU Shao-Xi   

  1. Institute of Derrmatology, Chinese Academy of Medical Sciences, Nanjing
  • Received:1988-08-30 Revised:1989-02-01 Online:1990-02-15 Published:1990-02-15

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摘要： 本文对30例寻常型银屑病患者和22例健康者的红细胞变形能力及膜ATP酶活性进行了检测,结果显示患者组红细胞变形能力较对照明显降低.Na+-K+ATP酶活性在病程一年以上组较对照组及病程一年以下组增高,Mg++ATP酶活性在病程一年内组较对照组降低,结果均有纷汁学显著意义.显示木病异常除表皮外还涉及其它组织细胞.

Abstract: Thirty gatients (male 15,female 15) with psoriasis valgaris from outhatient department were investigated by measuring erythrocyte fltcrability (deformability) and ATPase activity of erythrocyte membrane.22 healthy persons (male 10,female 12) served control.It was found that the index of erythrocyte filterability was sisynificantly higher (P<0.001) in the psoriatic group (0.508±0.037) than in that of the control group (0.320±0.023).The Na+K+ ATPase activity of erythrocyte membrane markedly elevated in the paoriatic group with the course of disease > 1 year (0.704±0.123) compared with the control group (0.421±0.029) or with the psoriatic group with the course of disease < 1 year (0.384±0.070),P<0.05.The Mg++ ATPase activity of erythrocyuc membrane reduced in the psoriatic group with the course of disease < 1 year (1.024±0.209) Compared with controt group (1.813±0.138),P<0.05.The results showed that not only the iceratinocytes but also the erythrocytes domonstrated abnormal alterations in patients with psoriasis.