中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (1): 25-26.

• 论著 • 上一篇    下一篇

SLE病人伴白细胞减少机制的研究

胡钧培, 谢文洁, 周桂兰, 钱六妹, 沈志祥, 陈淑蓉, 徐慧珍, 陈泽仪   

  1. 上海第二医科大学瑞金医院
  • 收稿日期:1988-05-04 修回日期:1988-08-26 出版日期:1990-02-15 发布日期:1990-02-15

STUDY ON THE PATHOGENESIS OF LEUCOPENIA IN SLE

HU Jun-Pei, XIE Wen-Jie   

  1. Ruijin Hospital, Shanghai Second Medical University
  • Received:1988-05-04 Revised:1988-08-26 Online:1990-02-15 Published:1990-02-15

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摘要： 应用体外双层软琼脂培养技术,检查SLE伴白细胞减少病人的血清与淋巴细胞对正常CFU-GM的作用.发现二者均可抑制CFU-GM生长.提示在SLE病人中免疫机制可能损伤骨髓中各种造血细胞,引起不同程度的血液学改变.

Abstract: The sera and/or periheral Iymphocytrs from SLE patients with Ieucopenia were examined by using the: double layer soft agar assay method for their inhibitory activity to normal colony forming unite-granulocyte-monocyte(CRU-GM).In these cases,either sera or lymphocytes supressed normal txuman bone marrow CFU-GM growth.The results suggest at imanune mechanism in the 8LE patients might impair hemahaietic progenitors in the bone marrow,causing various hematologic disorders.