中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (6): 369-371.

• 论著 • 上一篇    下一篇

银屑病血浆中6-酮-前列腺素F1α与cAMP, cGMP相关的研究

陈建中1, 李锡麟2   

  1. 1. 中国人民解放军第九八医院皮肤科;
    2. 南京铁道医学院附院同位素科
  • 收稿日期:1988-04-01 修回日期:1989-03-23 出版日期:1989-12-15 发布日期:1989-12-15

STUDY ON CORRELATION OF cAMP, cGMP WITH 6-K-PGFIa IN PLASMA OF PATIENTS WITH PSORIASIS WLGARIS

CHEN Jian-Zhong1, LI Xi-Lin2   

  1. Chinese People's Liberation Army 98th Hospatal
  • Received:1988-04-01 Revised:1989-03-23 Online:1989-12-15 Published:1989-12-15

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摘要： 作者测定了39例寻常型银屑病进行期患者及15例健康人的血浆6-酮-前列腺素F1α(6-K-PGF1α)与cAMP、cGMP.结果患者组6-K-PGF1α均值为114.26±23.19pg/ml,cAMP均值14.71±3.82pmol/ml,同正常人比较差异非常显著(均P<0.0I),cGMP均值8.20±1.54pmol/ml,明显高于正常人(P<0.01).cAMP/cGMP比值正常人与患者之比为3.06/1.79(P<0.01).经直线相关回归分析,发现6-K-PGF1α.与cAMP成正相关(r=0.498,P<0.01),与cGMP呈负相关(r=-0.385,0.01<P<0.05)的讨论了三者在银屑病发病中的作用与相互关系.

Abstract: The values of 6-Keto-Prostaglandin F1α (6-K-PGF1α),cAMP and cGMP in plasma from 39 patients with psoriasis vulgaris and normal persons were assayed.The results showed that the mean value of 6-K-PGF1α from patients was 114.26±23.19pg/ml and that of cAMP was 14.71±3.82 pmol/ml.In comparison with normal persons,the difference was very significant (P <0.01).The mean value of cGMP of the patients was 8.20±1.54pmoI/ml,signif candy higher than that of normal persons (P <0.01).The ratio of cAMP/cGMP for normsl persons and patients was 3.06/1.79 (P<0.01).By linear correlation and regresson analyses,6-K-PGF1α was found to be positive correlation with cAMP (r=0.498 P<0.01) and negative correlation with cGMP (r=-0.358,0.011α,cAMP and cGMP in psoriasis are discussed in this article.