中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (6): 366-368.

• 论著 • 上一篇    下一篇

各类型麻风皮损内T细胞亚群的研究

刘于君1, Skinsnes OK1, 丘钜世1, 何映芳2, 方郭锡2, 罗灵操2   

  1. 1. 中山医科大学病理教研室;
    2. 广州市皮肤病防治所
  • 收稿日期:1988-09-05 修回日期:1989-04-22 出版日期:1989-12-15 发布日期:1989-12-15

IN SITU CHARACTERIZATION OF T LYMPHOCYTE SUBSETS IN VARi0U5 TYPES OF LEPROSY

LIU Tze-Chun1, SKINSNES OK1   

  1. SUN Yal-Sen Uniaersity of Medical Science, Guangzhou
  • Received:1988-09-05 Revised:1989-04-22 Online:1989-12-15 Published:1989-12-15

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摘要： 本文应用单克隆抗体和免疫酶标技术,分析了30例各类型麻风皮损(包括TT6例,BT4例、BB1例、BL6例及LL13例)内Leu4、OKT4,及OKT8细胞的数量及其分布特点,发现Leu4细胞在TT型数量较多,并多分布在肉芽肿周围,而在LL型则量少而弥漫分布于病灶内.OKT4/OKT8平均比值从TT型端移行至LL型端时呈逐渐下降趋势,故LL的OKT8细胞相对显得增多.TT型及BT型尚见OKT4与OKT8细胞分布上呈分离现象.这均说明TT型及BT型病变免疫反应较明显.本文尚发现表皮与毛囊内有OKT4及OKT8细胞浸润,较多见于TT型及BT型,但OKT8细胞浸润较多见于LL型,对其意义亦加以讨论.

Abstract: Using monoclonal antibodies and immunoperoxidase technique,the numbers and distribution of T lymphocyte subsets in the skin lesions of various types of leprosy (including TT 6 cases,BT 4 cases,BB 1 case,BL 6 cases,and LL 13 cases) were determined and compared with each other.We found large amount of Leu 4 cells al the periphery of the TT granuloma,while the least number of this cells scattered loosely and admixed with the leprous cells in LL.The OKT4/OKT8 ratio was much higher in the TT polar type,with gradually declining towards another pole of the spectrum in LL type,e.g.,TT (1.76) > BT(1.13) > BB (1.1) > BL(1.03) > LL(0.45).It showed that OKTB cells were relatively increased in LL.The pattern of segregation of OKT4 and OKT8 cells at the periphery of the granuloma were shown in TT as well as in BT,but was better developed in the former.All these may reflect immunohistologically a cell-mediated immune response seen in both TT and BT.In addition,we found infiltration of OKT4 and OKT8 cells in the epidermis as well as in the hair follicles,which were easily seen in TT and BT.Infiltration of OKT8 cells were more encountered in LL,and their significance was also discussed.