中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (2): 99-102.

• 论著 • 上一篇    下一篇

酶处理的人精子头核免疫荧光试验对SLE的临床意义

陈孟禄, 陈曼, 李世荫   

  1. 北京医科大学第三医院
  • 收稿日期:1987-10-15 修回日期:1988-04-14 出版日期:1989-04-15 发布日期:1989-04-15

CLINICAL SIGNIFICANCE OF ENZYMEYSED HUMAN SPERMATOZOA NUCLEI IMMUNOFLUORESCENCE TEST FOR SLE

CHEN Meng-Lu, CHEN Man   

  1. Third Hospital,Beijing Medical University
  • Received:1987-10-15 Revised:1988-04-14 Online:1989-04-15 Published:1989-04-15

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摘要： 本文通过刘100例SLE患者的检测、动态观察和临床分析,进一步证实,酶处理的人精子头核免疫荧光试验在本组SLE的阳性率为65%活动期为92.2%.其阳性率及阳性滴度的几何均数随疾病的活动度降低而减少,病期间有显著性差异.本法阳性组肾损率增多,持续阴性者临床缓解率在77.8%以上.故本法的结果对于诊断SLE和判断其病情轻重有重要意义,其动态变化不同程度地反映了治疗效果和疾病预后.

Abstract: Serum AnDNA levels detected by ESN and clinical observation of 100 cases of SLE in different periods were analylized.It was found that the positive rates of ESN were 65.0% in all patients and 92.2% in patients in active period.The positive rates and geometric mean of positive titers decreaxd consistently with the improvement of patient's condition.The positive rates in different periods differed significantly.In the ESN poitive group,the incidence of renal involvement was higher than that of negative group.The clinical alleviative rate was 77.8% in persistently negative group.It is the author's option that ESN is of great value for the diagnosis,evaluation of activity,therapeutic effect and estimation of prognosis in SLE.