中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (5): 265-268.

• 论著 •    下一篇

RFP, 8663和DDS联合治疗多菌型麻风的现场研究—三年结果

李文忠1, 叶干运1, 陶明波2, 骆钧2, 杨忠民1, 王传基2, 冯璧2, 未学思2, 吕绍泉2, 季峰3, 王惠彬2, 贺挺书2, 丁镇之2, 吴家庆2, 陶期2, 张新华2, 高慈1, 周武庆1   

  1. 1. 中国医学科学院皮肤病研究所;
    2. 扬州市皮肤病防治所暨协作医院;
    3. 江苏省东台县皮肤病防治所
  • 收稿日期:1987-06-04 修回日期:1987-10-14 出版日期:1988-10-15 发布日期:1988-10-15

EFFECT OF TREATMENT WITH RIFAMPICIN, CLOFAZIMINE AND DAPSONE IN MULTIBACILLARY LEPROSY IN THE FIELD FOR THREE YEARS LI

LI Wen-Zhong1, YE Gan-Yun1   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing
  • Received:1987-06-04 Revised:1987-10-14 Online:1988-10-15 Published:1988-10-15

PDF (PC)

341

赞

摘要： 本文报告198 3-1986年间扬州市及东台县活动性多菌型麻风用RFP,B663和DDS联合治疗3年的可行性及疗效.3年来该地皮肤涂片阳性的多菌型麻风共591例,接受联合治疗者569例(96.3%),每年RFP和B663的监服率分别为96.7%,94.04%和93%.在可供3年结果分析的303例中,196例(64.7%)显示皮肤涂片阴转或临床不活动,其余均有不同程度的进步.皮肤查菌BI每年平均下降0.78,ENL和神经炎的发生频率随着疗程的增加而明显减少,未见其它严重毒副作用.初步结果提示本研究方案的可行性及疗效是满意的.3年治疗期间皮肤涂片阴转的196例中已有139例停药观察一年,均未见复发.

Abstract: The feasibility and effect of treatment with rifampicin (RFP), clofazimine (B663) and dapsone in multibacillary leprosy in Yangzhou District and Dongtai county of Jiangsu Province for three years are reported. There were 591 cases of active multibacillary leprosy in the study in three years, 569 (96.3%) of them being treated with this regimen. The monthly supervising rates of RFP and B663 during each of the 3 years were 96.7%, 94.04% and 93% respectively: Among 303 cases available for three years' analysis of the effect of treatment, 196 cases (64.7%) showed negative skin smears and clinical inactivity.