中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (3): 145-147.

• 论著 • 上一篇    下一篇

正常人血清抗角蛋白抗体的免疫组织化学研究

刘玉峰1, 车乃增1, 刘彦仿2, 丁华野2, 张泰山1, 祝连庆1   

  1. 1. 第四军医大学西京医院皮肤科;
    2. 第四军医大学病理解剖学教研室
  • 收稿日期:1987-02-09 修回日期:1987-06-24 出版日期:1988-06-15 发布日期:1988-06-15

IMMUNOHSTOCHEMICAL STUDY OF THE ANTI-KERATIN AUTOANTEBODY IN NORMAL HUMAN SERA

Liu Yufeng1, Che Naizeng1   

  1. Xi-jing Hospital, The Fourth Military Medical College
  • Received:1987-02-09 Revised:1987-06-24 Online:1988-06-15 Published:1988-06-15

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摘要： 本文以正常人皮肤冰冻切片为抗原组织,用间接免疫荧光技术发现正常成人血清中广泛存在一种抗角蛋白的自身抗体,该抗体的阳性反应主要发生于角层与粒层之间.分别用IgG,A,M检测正常成人血清105份、28份、28份,其发生率IgG66.67%,IgA100%,IgM96.43%.抗角蛋白抗体无种属的特异,但有器官特异性,其发生率与性别、血型无关.

Abstract: An autoantibody was found in normal human sera, which can react with keratin on the cryostatic sections of normal human skin by the indirect immunofluorescence method. The fluorescence is mainly located between the stratum corneum and the stratum Tranulosum. 105 normal adult sera were tested for IgG autoantibody with a positive rate of 66.67%.