免疫活性细胞对白念珠菌的反应

中华皮肤科杂志

免疫活性细胞对白念珠菌的反应

康克非

1. Case Western Reserve University 美国;
2. 杭州市第三人民医院 310009

收稿日期:2006-03-06 出版日期:2006-04-15 发布日期:2006-04-15

1. Case Western Reserve University 美国;
2. 杭州市第三人民医院 310009

Received:2006-03-06 Online:2006-04-15 Published:2006-04-15

摘要/Abstract

摘要： 在真菌中,除浅部真菌外,念珠菌仍然是最常见的致病性真菌.由于它常在机体免疫机能受损情况下感染,又归为机会致病性真菌.引起致病的念珠菌一直以白念珠菌居首位,根据近年来的报道^[1],引起念珠菌血症的除白念珠菌(40%～60%)外,其次为近平滑念珠菌(C.parapsilosis,20%～30%),热带念珠菌(C.tropicalis)和光滑念珠菌(C.glabrata,<5%),有些念珠菌也偶能致病如克柔念珠菌(C.krusei).虽然抗真菌药多年来有所增新,如氟康唑(fluconazol)、伏力康唑(voriconazol)、米卡芬净(micarfungin)等,由于药物的毒性及菌株可能产生的耐药性,因此了解和认识机体对菌体的反应,提高宿主对念珠菌的免疫能力,是值得关注和深入研究的,由此也可进一步提高药物的疗效.

康克非. 免疫活性细胞对白念珠菌的反应[J]. 中华皮肤科杂志, 2006, 39(8): 486-488.

参考文献

1 Fridkin SK.The changing face of fungal infections in health care settings.Clin Infect Dis.2005,41:1455-1460.
2 Sutmuller RPM,den Brok MHMGM,Kramer M,et al.Toll-like receptor controls expansion and function of regulatory T cells.J Clin Invest,2006,116:485-494.
3 Zhang S.Li J,Jia X,et al.The expression of toll-like receptor 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice.J Huazhong Univ Sci Technolog Med Sci.2004.24;639-641.
4 Netea MG,Van Der Graaf CA,Vonk AG,et al.The role of toll-like receptor(TLR)2 and TLR4 in the host defense against disseminated candidiasis.J Infect Dis,2002.185:1483-1489.
5 Netea MG,Sutmuller R,Hermann C,et al.Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.J Immuno1.2004,172:3712-3718.
6 Van der Graaf CA,Netea MC.Verschueren I,et al.Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae.Infect Immun.2005,73:7458-7464.
7 Smlnoky G,Bata-Csorgo Z,Kenderessy AS,et al.A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans.J Invest Dertnatol.2001.117;205-213.
8 Romani L,Montagnoli C,Bozza S,et al.The exploitation of distinct regconition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans.Intemational Immunol,2004,16:149-161.
9 Fe d'Ostiani C,Del Sero G,Bacci A,et al.Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans Implication for initiation of T helper cell immunity in vitro and in viva.J Exp med,2000,l91:1661-1673.
10 Xiong J,Kang K,Liu L,et al.Candida albicans and Candida krusei differentially induce human blood mononuclear cell interleukin-12 and gamma interferon production.Infect Immun,2000,68;2464-2469.
11 Liu L,Kung K,Takahara M,et al.Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes:Inhibitory role of C albicans germination.Infect Immun.2001,69;4695-4697.
12 Tang N,Liu L,Kang K,et al.Inhibition of monocytic interleukin-12 production by Candida albicans via selection activation of ERK mitogen-activated protein kinase.Infect Immun,2004,72:2513-2520.
13 Luo X,Liu L,Tang N,et al.Inhibition of monocyte-derived dendritic cell differentiation and interleukin-12 production by complement iC3b via a mitogen-activated protein kinase signalling pathway.Exp Dermato1,2005,14:303-310.
14 Pulg-Kroger A,Relloso M,Femandez-Capetillo,et al.Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells.Blood,2001,98;2175-2182.