中华皮肤科杂志 ›› 1985, Vol. 18 ›› Issue (4): 191-194.

• 论著 •    下一篇

868株化脓性皮肤病金黄色葡萄球菌的噬菌体分型和对抗菌药物的敏感性

王荷英, 卢婉乔, 叶顺章, 曹元华, 樊红霞, 喻林冲, 黄鸿生   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1984-11-21 修回日期:1985-03-05 出版日期:1985-12-15 发布日期:1985-12-15

Study on phage-type of staphylococcus aureus in pyoderma patients and their sensitivities to antibiotics

Wang Heying   

  • Received:1984-11-21 Revised:1985-03-05 Online:1985-12-15 Published:1985-12-15

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摘要： 将从北京、泰州二地化脓性皮肤病患者分离的368株金黄色葡萄球菌用23株国际标准噬菌体进行了分型,并用15种抗生素和抗菌药物进行了药物敏感性测定.结果表明可分型菌株为242株(占66%),能定为93种不同的噬菌体谱型,属混合组最多(38.4%),在混合组中又以工组/其它(81,94,95,96型)噬菌体谱型的比例最高(51.6%).耐药比例较高的为SD(92.6%)、青霉素(81.3%).SMZ+TMP(Co-trimoxazole 56.7%)、四环素(55.3%)和链霉素(31.3%).文中对噬菌体谱型同对抗菌素耐药性关系以及化脓性皮肤病感染的关系进行了分析,并以噬菌体分型为依据,提出了制作多价菌苗治疗慢性、顽固的葡萄球菌性脓皮病的设想.

Abstract: Three hundred and sixty-eight strains of staphylococcus aureus isolated from pyoderma patients in Beijing and Taizhou were phage-typed with 23 international standard phages, and their sensitivities to 15 antibiotics and other drugs were determined.The results showed that 242 strains could be typed(66%) as 93 different phage-patterns, most of them belonged to the mixed groups, in which Group I/other phage types(81, 94, 95, 96),were of highest incidence(51.6%).The bacteria developed resistance to many drugs, in which the most common ones were as follows; sulfadiazine(92.6%), penicillin G.(81.3%).sulfamthoxazole-f-TMP (Co-trimoxazole)(56.7%).tetracycline(55.3%) and streptomycin(31.3%).In this paper, the relation between phage-type and drug resistance as well as the relation between phage-type and pyoderma infection were analysed. According to the phage-typing, the autliors put forward the envisagement that multivalent vaccine may be useful for the treatment of chronic obstinate stapliylococca pyoderma.