中华皮肤科杂志 ›› 1985, Vol. 18 ›› Issue (1): 28-31.

• 论著 • 上一篇    下一篇

用比例杀菌试验探讨几种抗麻风药物的杀菌效果

纪宝宏, 王士玉, 倪国兴, 侯玉鸿   

  1. 上海遵义医院
  • 收稿日期:1983-09-06 修回日期:1983-11-27 出版日期:1985-03-15 发布日期:1985-03-15

Qbservation on bactericidal activity of several drubs against M. Leprae by proportional bactericidal test

Ji Baohong   

  • Received:1983-09-06 Revised:1983-11-27 Online:1985-03-15 Published:1985-03-15

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摘要： 比例杀菌试验通过计算最可能活菌数(MPN)和半数感染菌量(ID50)可以确定和比较药物对麻风菌的杀菌效果.本文报告用比例杀菌试验发现两种新型利福霉素SV的半合成衍生物——异丁基呱嗪利福霉素(R-76-1)和甲肘利福霉素(AF-MO)的杀菌效果明显超过利福平和氨苯砜.

Abstract: The prooprtional bactericidal test(PBT)can be used to assess and compare the bactericidal acjivity of drugsagainst M.Leprae through the estimation of the most probable number(MPN)of viable bacilli and the number of AFB necessary to infect 50% of the mice, i.e. ID50 The bactericidal activity of two new rifamycin SV derivatives, i.e, isobutyl-piperazinplrifamycin SV(R-76-1)and methyloxime of 3-formylrifamycin SV(AF-MO),was significantly superior than that of rifampicin and dapsone by PBT.