中华皮肤科杂志 ›› 1984, Vol. 17 ›› Issue (4): 253-254.

• 论著 • 上一篇    下一篇

银屑病光化疗法前后淋巴细胞姐妹染色单体互换率

刘德祥1, 殷学军1, 李厚钧1, 王河川1, 艾辉1, 高效贤1, 吕俊元2   

  1. 1. 乌鲁木齐部队总医院遗传室;
    2. 乌鲁木齐部队总医院遗传室皮肤科
  • 出版日期:1984-12-15 发布日期:1984-12-15

Study of sister chromatid exchange rates in lymphocytes of psoriatic patients before anb after PUVA treatment

Liu Dexiang1   

  • Online:1984-12-15 Published:1984-12-15

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摘要： 本文对银屑病患者光化疗法前后淋巴细胞姐妹染色单体互换率进行了比较.结果表明:全部43名银屑病患者治疗前SCEX±SE=6.48±0.20.其与116个健康人SCEX±SE=6.48±0.11相比,与非银屑病21人SCEX±SE=6.22±0.27相比无显著差异(P>0.05).说明银屑病患者自身SCE水平并不高.光化治疗后与光化治疗前相比,SCE水平显著提高(P>0.001).平均增加1.91次.作者认为长期应用PUVA治疗银屑病患者可能有害.

Abstract: This paper reports a comparison between sister chromatid exchange (SCE) rates in lymphocytes of psoriatic patients before and after a course of PUVA treatment. The results showed that there are no significant differencas (P>0.05) in a comparison between 43 cases of psoriatic patients (SCEX±SE=6.79±0.20) before treatment, 116 healthy persons SCEX±SE=6.48±0.11) and 21 cases of non-pso-(riatic patients (SCEX±SE=6.22±0.27).It has been revealed that the level of SCE in our psoriatic patients is not so higth. In contrast to the SCE levels before PUPA treatment, the SCE levels increased remarkably (P<0.001) after PUPA treatment with an average increase of 1.91 times. It is thus considered that long-term PUPA treatment is possibly harmful for psoriatic patients.