中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (3): 165-167.

• 论著 • 上一篇    下一篇

乳房外Paget病的组织发生学研究

李宁, 郭英年   

  1. 北京医科大学第一医院皮肤科, 100034
  • 收稿日期:1992-01-28 修回日期:1992-10-09 出版日期:1993-06-15 发布日期:1993-06-15

Studies on the histogenesis of extramammary Paget’s dise ase

LI Ning, GUO Ying-Nian   

  1. The First Hospital, BeJing Medical University, Beijing 100034
  • Received:1992-01-28 Revised:1992-10-09 Online:1993-06-15 Published:1993-06-15

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摘要： 对14例乳房外Paget病(EMPD)进行了组化、免疫组化及病理、超微结构的研究,以探讨它的组织发生.结果表明,EMPD的Paget细胞可能源于表皮内多潜能的胚芽细胞,并具有向汗腺分化的能力.

关键词: Faget病, 乳腺外

Abstract: In an attempt to define the histogenesis of Paget cell, 14 cases of extramammary Paget's disease (EMPD) of genitocrural region were investigated by histopathologic, ultrastructurai, histochemical and PAP-immunohistochemical methods. Histologically, Paget cell located only within epidermis or/and within the epithelium of appendages in most cases (12/14). The results of immunostains with monoclonal antibodies such as CEA, EMA, S-100, cytokeratin K27 and HK2 showed that Paget cell was positive to CEA, EMA, HK2 and was negative to 5-140 and K27. Paget cell was also positive to PAS and Alcian blue. The pattern of immunostaining in EMPD was sinular tp that in eccrine poroma. Ultrastructural study showed that Paget cell had the characteristics of both glandular cell and keratinocyte. The results of nur study lead us to think that the Paget ccll of EMPD probably derived from the pluripotential epidermal germinative cell which may be differentiated to aporsine or eccrine direction.

Key words: Paget’s disease, extramammary