中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (3): 165-167.

• 论著 • 上一篇    下一篇

青蒿琥酯对小鼠变应性接触性皮炎及白细胞介素1的影响

王俐, 高玉祥   

  1. 安徽蚌埠医学院皮肤病学教研室 233004
  • 收稿日期:1991-01-21 修回日期:1991-08-14 出版日期:1992-06-15 发布日期:1992-06-15

Effects of artesunate on allergic contact dermatitis and interleukin 1

WANG Li, GAO Yu-Xiang   

  1. Bengbu Medical College, Anhui, 233004
  • Received:1991-01-21 Revised:1991-08-14 Online:1992-06-15 Published:1992-06-15

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摘要： 用青蒿琥酯对实验性变应性接触性皮炎的致敏前,激发时,激发后12小时三个不同阶段进行研究,结果表明:青蒿琥酯用于致敏前,激发后12小时对皮炎的抑制作用最为明显.此外用青蒿琥酯对小鼠体内、外巨噬细胞分泌白细胞介素I(IL1)活性进行测定,结果显示:青蒿琥酯对体内外IL1活性均有抑制,提示青蒿琥酯是一种很有前途的免疫调节剂,临床可推广用于治疗湿疹皮炎.

关键词: 青蒿琥酯, 皮炎,接触性, 白细胞介素1

Abstract: Artesunate is one of the derivatives of Qinghaosu (Artemisin),a compound prepared from the medicinal herb Qinghao Cartemisia annua L). It has been noticed that artesunate posesses an lmmunosuppressive activity.In this paper, we studied the action of artesunate ort different phases (sensitization,challenge,and 12h after challenge) of allergic contact dermatitis. It showed that artesunate had prominent suppressive effect when it was used prior to sensitization and 12h after challenge.

Key words: Artesunate, Dermatitis, contact, Interleukin 1