中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (5): 304-306.

• 论著 • 上一篇    下一篇

皮肤良恶性疾病皮损中核仁组成区相关蛋白的研究

王建力1, 张振楷1, 陈莉2, 徐健2, 肖玉风2   

  1. 1. 南通医学院附属医院皮肤科, 江苏 226001;
    2. 南通医学院病理解剖教研室
  • 收稿日期:1990-03-24 修回日期:1990-11-02 出版日期:1991-10-15 发布日期:1991-10-15

Nucleoiar Organizer Regions Associated Proteins (AgN0Rs) in Benign and Mauigaaat Skin Diseases

WANG Jian-Li1, ZHANG Zhen-Kai1   

  1. Nantong Medical College
  • Received:1990-03-24 Revised:1990-11-02 Online:1991-10-15 Published:1991-10-15

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摘要： 用核仁组成区相关蛋白(AgNORs)嗜银染色技术,研究了68例不同皮肤病变病损中细胞核中的AgNORs.结果显示:皮肤恶性肿瘤细胞核中AgNORs数量显著高于良性病变.在恶性肿瘤中基底细胞癌细胞核中AgNORs的数量显著高于其它类型的恶性肿瘤,在皮肤鳞癌中癌细胞分化越差,癌细胞核内AgNORs数量越多.在皮肤良性病变中,皮角细胞核中AgINORs显著高于脂溢性角化病,后者又显著高于银屑病.此外AgNORs在不同病变细胞核有一定的分布形式,恶性病变中AgNORs主要以卫星粒状分布.在良性病变中主要为网状团块分布.我们认为AgNORs技术有助于皮肤肿瘤的诊断.

Abstract: A silver cofloid technique to identify uxcleolar organizer region associated proteins (AgNORs) has been applied to 68 skin diseases.The results showed that in malignant skin diseases AgNORs per nucleus increased significantly than those in benign skin diseases.AgNORs per nucleus in basal cell carcinomas were much more than those in other neoplasms.In squamous cell carcinomas,the number of AgNORs was related to the differentiation of malignant cells,the less the differentiation,the more the number of AgNORs.