中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (4): 248-250.

• 论著 • 上一篇    下一篇

肾上腺皮质激素对骨矿物质含量的影响

魏发荣1, 杨定焯2, 罗汉超1, 陆右之1, 李萍1, 曾华1, 李毅2, 周光平1   

  1. 1. 华西医科大学第一附属医院皮肤科, 成都, 610041;
    2. 职业病医院放射科
  • 收稿日期:1990-02-13 修回日期:1990-06-21 出版日期:1991-08-15 发布日期:1991-08-15

Lnfluence of glucocorticoids on boue mineral contents

WEI Fa-Rong1, Yang Ding-Chuo2   

  1. The First Affiliated Hospital, West China Medical University, Chengdu
  • Received:1990-02-13 Revised:1990-06-21 Online:1991-08-15 Published:1991-08-15

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摘要： 用γ线单光子吸收法,对明例使用肾上腺皮质激素者的桡骨作了骨矿物质含量测定.结果比正常对照组明显降低,在激素累积量达强的松2000mg,或大剂量连续使用30天至减至维待量的阶段,骨矿物质含量最低,是发生严重骨质疏松并发症的危险期,必须密切观察并作相应处理.部分病人有血钙、磷、碱性磷酸酶和尿钙、磷异常,对其临床意义作了探讨.

Abstract: We measured bone mineral intents (BMC) in radius of 89 patients who trcatcxl with glucocorticoids by single photon absorptimetry. The BMC reduced significantly than noimal control group. The level of BMC was lost when the cumulating dose of glucooorkiaoida reached to 2000 mg of prednisone or after continuous trcattnent with large doses of glucocorticoids for 30 days, and then tapered to maintenance dose. This is a high risk period for the occurrencx of osteoporosis. Therefore we suggest that dose attention have to be paid to the BMC of the patients during this period and antiosteoporosis treatment be given. Some biochemical abnormalities were observed in our patients, the clinical significan of them were discussed.