中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (4): 245-247.

• 论著 • 上一篇    下一篇

四种双吲哚类药物的实验药理研究及其临床意义的探讨

涂彩霞1, 林熙然1, 杨春梅1, 苗琦1, 卜松樵2   

  1. 1. 大连医学院皮肤病学教研室, 辽宁, 116011;
    2. 第一附属医院核医学科
  • 收稿日期:1990-02-12 修回日期:1990-10-15 出版日期:1991-08-15 发布日期:1991-08-15
  • 基金资助:
    国家自然科学基金资助裸题

A study on the pharmacologic activities of 4 kinds of di-indole compound in relation to treatment of psoriasis

TU Cai-Xia1, LIN Xi-Ran1   

  1. The First Hospital, Dalian Medical College, Liaoning
  • Received:1990-02-12 Revised:1990-10-15 Online:1991-08-15 Published:1991-08-15

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摘要： 利用小鼠阴道上皮和取尾鳞片表皮两个实验动物模型,对异靛甲及其他3种双吲哚类药物进行了与银屑病相关的实脸药理研究.实验结果支持异靛甲治疗银屑病的临床观察,为其扩大临床应用提供药效学依据.实验络果还表明3种双吲哚类药物促进表皮正常角化的作用大于抑制细胞有丝分裂的作用,且均有提高小鼠血浆cAMP/cGMP比值的作用,提示它们的作用方式不同于一般细胞毒药物,对银屑病的治疗作用可能与提高cAMP/cGMP比值有关.

Abstract: Employing mouse vaginal epithelium and modle tail scale epidermis as experimental modals,the authors studied the pharmacologic activitire of N-methyIisoindigotin (meisoindigo) sad other 3 di-ixtdole compounds in relation to the treatment of psoriasis. The results supported the previous clinical observation on treating psoriasis with meisoindigo and provided the pharmacodynamic basis for the clinical use of the drug. The promotive effect om orthokeratinization of the 4 di-indole compounds studied was obsezved to be stronger than the inhibitory effect on mitmsis, suggesting that tine mode of action of these compounds be different from cytotaxica. All of the 4 compondsn significantly raised the plasma cANP/cGMP ratio in mice, suggesting a possible mechanism of the effect of these compounds in relatiou to the treatment of psoriasis.