中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (2): 81-83.

• 论著 • 上一篇    下一篇

SLE皮损内浸润细胞免疫组织化学表现型的研究

吴南燕1, 顾绍裘2   

  1. 1. 佳木斯医学院附属医院皮肤科;
    2. 中国医科大学附属第一医院皮肤科
  • 收稿日期:1989-08-22 修回日期:1989-12-14 出版日期:1991-04-15 发布日期:1991-04-15
  • 基金资助:
    国家自然科学基金资助课题

Study of irnmanohistochenucal phenotype of the infiltrates in systemic lupus erythematosus

WU Nan-Yan1, GU Shao-Qiu2   

  1. Affiliated Hospital, Jiamusi Medical College
  • Received:1989-08-22 Revised:1989-12-14 Online:1991-04-15 Published:1991-04-15

摘要: 应用几种单克隆及多克隆抗体借助亲和素-生物索-辣根过氧化物酶复合物技术(ABC技术),对16例系统性红斑狼疮(SLE)皮损的冰冻切片进行了分析.所有患者的爽皮浸润细胞中大多数是T细胞(Leu 4+),未见B细胞.而且这些细胞中多数为Ia+细胞,说明是处于激活状态的T细胞.TH/I(Leu3 a+)细胞占有优势,TH/I与TS/C(Leu 2a+)细胞的比值为1.3:1~8.2:1,6例见角朊细胞表达Ia拉原,表现为毛襄着染,表皮中下部鱼网状着染,基底层至顺粒层鱼网状着染.上述结果提示细胞免疫参与了系统性红斑狼疮皮肤损害的发生.T细胞可能起了重要的作用.

Abstract: Frozen sections of skin lesions of 16 patients with systemic lupus erythmatasus (SLE) were analysed by the avidin-biotin-pcroxidase complex (ABA) technique, using a panel of monoclonal and polyclonaI antibodies. It was shown brat the majority of infiltrating cell,were T cells, a large number of tirwe cells were OKIa 1* ceiLs, indicating that they were in an activated state.