中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (6): 381-383.

• 论著 • 上一篇    下一篇

银屑病多发家系与HLA抗原相关的研究

曹凯, 宋芳吉, 李惠刚, 徐沈育, 刘忠环, 苏霄汉, 王凤贤   

  1. 中国医科大学附属第一医院皮肤科
  • 收稿日期:1989-06-04 修回日期:1990-02-19 出版日期:1990-12-15 发布日期:1990-12-15

STUDY OF ASSOCIATION BETWEEN HLA AND PSORIASIS VULGARIS

CAO Kai, SONG Fang-Ji   

  1. The First Hospital, China Medital University, Shenyang
  • Received:1989-06-04 Revised:1990-02-19 Online:1990-12-15 Published:1990-12-15

PDF (PC)

447

赞

摘要： 本文对12个具有两代寻常型银屑病病史的家系进行了HLA执原分型研究.结果HLA-A1,B13,B17,Cw4,Cw6抗原频率比对照组增高,HLA单倍型呈非随机分布;患病同胞共享两条或一条HLA单倍型的频率比期望的明显增高.银屑病疾病基因与HLA呈紧密连锁,本病的疾病基因与隐性遗传模型有很好的吻合度.

Abstract: We performed HLA typing fer all members of 12 families with more than one patients with psoriasis vulgaris in two generations.The phenotype frequencies of HLA-Al,B13,B17,Cw4,Cw6 in the patients were muchhigher than those in the controls.