中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (5): 270-271,274.

• 论著 • 上一篇    下一篇

SLE患者血清补体第二途径激活的探讨

葛以信1, 薛筑云1, 汤意诚1, 张美华1, 贾辅忠2, 孙南雄2, 韩亚萍2   

  1. 1. 南京医学院一附院皮肤科;
    2. 南京医学院一附院传染科
  • 收稿日期:1986-07-07 修回日期:1987-04-28 出版日期:1987-10-15 发布日期:1987-10-15

Study the activation of alternate complement pathway in SLE

Ge Yixin1   

  • Received:1986-07-07 Revised:1987-04-28 Online:1987-10-15 Published:1987-10-15

PDF (PC)

228

赞

摘要： 本文研究SLE发病过程中血清补体替代途径的活化.对36例SLE患者同时测定血清补体ACH50,B因子、CH50,C3和C4,其结果表明除经典途径活化外,替代途径亦被激活.其B因子不仅与SLE发病有关,而且与疾病的活动性相关.B因子的变化与C3,C4变化相一致,尤其在活动性SLE.

Abstract: This paper reports the study on the activation of alternate pathway of complement system during the pathological course of systemic lupus erythematosus (SLE). Serum levels of complement ACH50, B factor CH50, C3, C4 were measured in 36 patients with SLE.The results revealed that the alternate pathway of complement system in addition to the classical pathway were activated. B factor was not only related to the pathogensis of SLE but with the activity of the disease. The change of B factor correlated with the changes of C3 and C4, especially in the active phase of SLE.