中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (4): 204-206.

• 论著 • 上一篇    下一篇

SLE患者血清唾液酸水平的测定

郑沛枢, 冯树芳, 侯兰娣   

  1. 上海医科大学皮肤病学研究所
  • 收稿日期:1986-06-20 修回日期:1986-09-11 出版日期:1987-08-15 发布日期:1987-08-15

Determination of serum sialic acid in SLE

Zheng Peishu   

  • Received:1986-06-20 Revised:1986-09-11 Online:1987-08-15 Published:1987-08-15

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摘要： 为了评价血清唾液酸(SA)水平能否作为判断系统性红斑狼疮(SLE)患者疾病严重度和活动度的指标,作者等测定了47名SLE患者血清中的SA水平.结果发现,SLE患者血清SA水平较对照组明显升高(P<0.001),但SA水平除与尿蛋白严重度及血清白蛋白组分下降,α2球蛋白组分升高相关外,与疾病严重度及多种免疫指标均无相关关系,不能作为判断SLE患者疾病严重度和活动度的指标.结合数据,对血清SA升高的机理、意义及测定血清SA水平的局限性进行了讨论.

Abstract: The serum level of sialic acid (SA) of 47 patients with systemic lupus erythematosus (SLE)was determined. The results showed that the SA level of SLE patients was significantly elevated when compared with normal controls (P<0.001). The SA level paralleled with the severity of proteinuria, decline of serum albumin and elevation of α2 globulin. There were no correlations between SA level and the severity of disease and multiple immunologic parameters. Thus the serum SA level is an in appropriate parameter of the severity and acivity of SLE. The mechanism and significance of the elevation of serum SA were discussed.