Objective To investigate the clinical features of skin cancer. Methods Clinical data of skin cancer and precancerous skin lesions confirmed pathologically from 2005 to 2008 in Peking University First Hospital were retrospectively analyzed by using statistical methods. Results A total of 632 cases of skin cancer and precancerous skin lesions were studied. The most common skin cancer was basal cell carcinoma and squamous cell carcinoma （invasive and in situ） which accounted for 29.3% and 24.2%, respectively. The average age at onset was older than 60 years in 55.4% of the patients, between 35 and 59 years in 34.3%, younger than 35 years in 10.3%. The concordance between clinical and pathological diagnosis reached nearly 90.0% for Paget′s disease, 70.0% for other common skin cancer and precancerous skin lesions. Conclusions Skin cancer and precancerous skin lesions have a predilection for scalp and face. Patients aged from 35 to 59 years account for a significant proportion not only in cutaneous lymphoma but also in melanoma and epithelium-derived nonmelanoma skin cancer.