Chinese Journal of Dermatology ›› 2022, e20220028.doi: 10.35541/cjd.20220028

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Treatment of chronic hand eczema

Bai Lu, Chu Yan, Liu Yuanyuan, Zhu Caiyong   

  1. Department of Dermatology, The Hospital of No.80 Group Army of PLA, Weifang 261021, Shandong, China
  • Received:2022-01-12 Revised:2022-03-08 Online:2022-01-01 Published:2022-05-06
  • Contact: Zhu Caiyong

Abstract: 【Abstract】 Currently, topical glucocorticoids are still the first-line treatment of chronic hand eczema, while systematic treatment is required for moderate to severe chronic hand eczema with no response to topical corticosteroids. Traditional treatments include glucocorticoids, antihistamines, retinoids, immunosuppressants, etc. In recent years, some progress has been made in the treatment of chronic hand eczema with Janus kinase inhibitors, phosphodiesterase 4 inhibitors, biological agents, statins, timolol, daylight photodynamic therapy, etc. This review summarizes recent advances in the treatment of chronic hand eczema, including basic therapy, topical treatment, physical therapy and systemic therapy.

Key words: Eczema, Molecular targeted therapy, Phosphodiesterase 4 inhibitors, Therapy, Chronic hand eczema, Dupilumab, Janus kinase inhibitors