Abstract: 【Abstract】 According to the new biopsychosocial medical model, status and burden of diseases should be evaluated comprehensively, and health-related quality of life can be an important measurement index of the burden of diseases. Conventional assessment methods for health-related quality of life include interval-based assessment methods and preference-based assessment methods （health utilities and willingness-to-pay）. This review introduces willingness-to-pay, and summarizes its applications in skin diseases. However, at present, only a small quantity of small-scale studies are available on willingness-to-pay, with only a few kinds of skin diseases involved. In the application of health-economic assessment of skin diseases, willingness-to-pay can serve as an approximate index of benefit gains, and be more valuable in practice than health utilities （the index of utility gains）. With the increase in health-economic researches on skin diseases, more attention is paid to the willingness-to-pay for skin diseases and other health-economic assessment methods, and large-scale health-economic assessment-related researches are expected to be conducted on more kinds of skin diseases.

Key words: Skin diseases, Cost of illness, Quality of life, Willingness?to?pay, Health utilities