中华皮肤科杂志 ›› 2022, e20210858.doi: 10.35541/cjd.20210858

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表皮生长因子受体抑制剂相关甲沟炎的研究进展

胡紫馨1,2    谭可欣1,2    董慧静1,2    张旭1,2    俞仪萱1,2    鲁星妤1,2    李嘉1,2    崔慧娟2   

  1. 1北京中医药大学,北京  100029 2中日友好医院中西医结合肿瘤内科,北京  100029
  • 收稿日期:2021-11-26 修回日期:2022-05-19 发布日期:2022-08-31
  • 通讯作者: 崔慧娟 E-mail:chjzryhyy@sina.com
  • 作者简介:作者毕业需要,希望4月份出录用证明
  • 基金资助:
    国家自然科学基金(81873396);首都卫生发展科研专项项目(首发2018-2-4065)

Epidermal growth factor receptor inhibitor-related paronychia

Hu Zixin1,2, Tan Kexin1,2, Dong Huijing1,2, Zhang Xu1,2, Yu Yixuan1,2, Lu Xingyu1,2, Li Jia1,2, Cui Huijuan2   

  1. 1Beijing University of Chinese Medicine, Beijing 100029, China2Department of Oncology, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2021-11-26 Revised:2022-05-19 Published:2022-08-31
  • Contact: Cui Huijuan E-mail:chjzryhyy@sina.com
  • Supported by:
    National Natural Science Foundation of China (81873396); Capital Funds for Health Improvement and Research (2018-2-4065)

摘要: 【摘要】 表皮生长因子受体抑制剂(EGFRI)相关甲沟炎是指与EGFRI治疗明确相关的以甲周皮肤红斑、水肿、脓性渗出、甲周或甲下肉芽组织病变,或伴甲板变薄变脆甚至碎裂分离为特点的疾病。表皮功能抑制、炎症形成并继发感染、血管新生是EGFRI相关甲沟炎发生发展的核心过程。本文综述EGFRI相关甲沟炎的流行病学、发病机制、临床表现、预防和治疗手段。

关键词: 甲沟炎, 表皮生长因子受体抑制剂, 皮肤毒性反应

Abstract: 【Abstract】 Epidermal growth factor receptor inhibitor (EGFRI)-related paronychia is a condition clearly related to EGFRI therapy, characterized by periungual erythema, edema, purulent exudates, periungual or subungual granulomatous lesions, and sometimes accompanied by thinning, fragility or even splitting and seperation of nail plates. Inhibition of epidermal function, inflammation and secondary infections, as well as angiogenesis are the core processes in the occurrence and development of EGFRI-related paronychia. This review summarizes epidemiology, pathogenesis, clinical manifestations, prevention and treatment of EGFRI-related paronychia.

Key words: Paronychia, Epidermal growth factor receptor inhibitors, Cutaneous adverse reactions

引用本文

胡紫馨, 谭可欣, 董慧静, 张旭, 俞仪萱, 鲁星妤, 李嘉, 崔慧娟. 表皮生长因子受体抑制剂相关甲沟炎的研究进展[J]. 中华皮肤科杂志, 2022,e20210858. doi:10.35541/cjd.20210858

Hu Zixin, Tan Kexin, Dong Huijing, Zhang Xu, Yu Yixuan, Lu Xingyu, Li Jia, Cui Huijuan. Epidermal growth factor receptor inhibitor-related paronychia[J]. Chinese Journal of Dermatology,2022,e20210858. doi:10.35541/cjd.20210858